Effect of natural solubilizers on the solubility and dissolution of aceclofenac

Aceclofenac, an insoluble anti-inflammatory drug, was incorporated in solid dispersions using different carriers; namely, hen, fish and rabbit gallbladder contents as natural solubilizers and polysorbate 80, sodium lauryl sulfate, sodium deoxycholate and lecithin/sodium deoxycholate [1:1] mixture as synthetic solubilizers. The solubility and dissolution of aceclofenac were investigated at pH 1.2 and 7.4 as a function of the solubilizer concentration [0-2% w/w] in the prepared solid dispersion. At pH 1.2, in a concentration of 2% w/w solubilizer, the drug solubility and dissolution were improved. The solubility increased from 1.24 mg/ml to 11.65 and 11.5 mg/ml when using hen bile and polysorbate 80, respectively. Dissolution was found to be a function of solubility, especially in case of natural solubilizers and polysorbate 80. Simple and/or mixed micellar solubilization was the main mechanism suggested for the increased solubility and dissolution of the drug. The results were confirmed by surface tension measurements of the aqueous solutions of the plain drug and its solid dispersions. Differential scanning calorimetry [DSC] and infrared spectroscopy [IR] studies suggested the possible interactions between aceclofenac and some of the used solubilizers

[Comparative dissolution study of drugs using protein hdrolysates]

Kneaded mixtures as well as physical mixtures, of an acidic drug, indomethacin, a basic drug vincamine, and a neutral drug, prednisolone, with gelatin and casein hydrolysates were prepared. Their in vitro dissolution profiles were examined. The dissolution of drugs from the kneaded mixtures was significantly increased compared to the drugs alone as well as their physical mixtures. This increase was most prominent for the acidic drug indomethacin. The casein and gelatin hydrolysates enhanced the dissolution of the three drugs by improving the wettability of the drug particles. Solubility also contributes to the enhancement of dissolution of indomethacin and prednisolone. Buffering was an additional reason in case of indomethacin

Comparative dissolution study of drugs using protein hydrolysates

Kneaded mixtures as well as physical mixtures, of an acidic drug, indomethacin, a basic drug, vincamine, and a neutral drug, prednisolone, with gelatin and casein hydrolysates were prepared. Their in-vitro dissolution profiles were examined. The dissolution of drugs from the kneaded mixtures was significantly increased compared to the drugs alone as well as their physical mixtures. This increase was most prominent for the acidic drug indomethacin. The casein and gelatin hydrolysates enhanced the dissolution of the three drugs by improving the wettability of the drug particles. Solubility also contributed to the enhancement of dissolution of indomethacin and prednisolone. Buffering was an additional reason in case of indomethacin