ABSTRACT
In this study, different biochemical parameters were investigated in 90 albino adult rats, Sprague-Dawely strain, divided into two groups [healthy and diabetic]. They were supplied with alitame and aspartame at 10, 50 and 100 mg/kg body weight/day for five weeks. No significant changes were reported in both groups in serum glucose, hemoglobin, total protein, albumin, globulin, A/G ratio and lipid pattern of healthy rats treated with alitame or aspartame at levels of 10 and 50 m/gkg body weight/day. However, a significant elevation was reported in serum glucose, total protein, globulin and A/G ratio at 100 mg/kg body weight/day for both sweeteners in healthy rats. Glucose was significantly decreased in diabetic rats fed alitame when compared with their corresponding control groups. Regarding liver enzymes, both sweeteners significantly elevated aspartate transaminase [AST] levels in healthy and diabetic groups. Alanine transaminase [ALT] and alkaline phosphatase [ALP] levels also increased in aspartame fed diabetic group. There were no statistical differences between the effect of alitame or aspartame on the biochemical aspects of healthy and diabetic rats except for liver enzymes level