ABSTRACT
Amyloidosis is less involved in the respiratory tract. The tracheobronchial amyloidosis is rare, and the amyloid changes involved in the larynx, trachea and bronchus are more rare. The study introduces a case of the primary laryngeal and tracheobronchial amyloidosis. The patient was diagnosed as primary laryngeal amyloidosis, and had tracheobronchial amyloidosis after 15 years. Due to the rare and non-specific clinical manifestations of the disease, the patient was misdiagnosed as upper respiratory tract infection and bronchial asthma.After the treatment of the clamp of the bronchoscope and argon knife,the symptoms were significantly relieved in the patient.At present,the disease is stable and has not relapsed,but it still needs to track the long-term prognosis.