ABSTRACT
This study is to elucidate the withdrawal of codeine and phenobarbiton and their effects on some brain, cardiac activity and glucose-insulin-glucagone relations. This may help to clarify the side effect and metabolic changes which may occur as a result of drug administration. For this aim forty adult albino rats were randomly divided to 5 groups each of eight animals. First group was kept as control. Second and third group received codeine orally in therapeutic and double therapeutic dose. Forth and fifth group were given phenobarbiton intramuscular in therapeutic and double therapeutic dose. Drugs were administered day after day for four consecutive weeks. Alterations in serum Monoamine oxidase [MAO] activities, Cholinesterase [ChE] activities, whereas 5' nucleotidase [5'NT] and creatine kinase [CK] activity lactate dehydrogenase [LDH], Aspartat-aminotransferase [AST], glucose, insulin and glucagon were recorded. Such alterations were discussed in relation to doses and levels of drugs in urine of rats that actually stopped drug and exhibited that the analgesic effects symptoms of the drugs are expression of changes of functioning enzymes