ABSTRACT
Background: Dental implant is an artificial tooth root fixed into the jaws to hold a replacement tooth or bridge. Functional surface modifications by organic material such as amelogenin coating seem to enhance early pert-implant bone formation. The aim of the study was to study the expression of osteocalcin and collagen I as bone formation markers in amelogenin coated and uncoated implant in interval periods [1,2,4 and 6 weeks]
Materials and Methods: Commercially pure Titanium [cpTi] implants, coated with omelogenin protein, were placed in the tibias of 40 New Zealand white rabbits, histological and immunohistochemical tests for detection of expression of osteocalcin and collagen / were performed on all the implants of both control and experimental groups for [1,2,4 and 6 weeks] healing intervals
Results: Histological finding for coated titanium implant with amelogenin illustrated an early bone formation, mineralization and maturation in comparison to control. Immunohistochemical finding showed that positive reaction for osteocalcin and collagen I was expressed by osteoblast cells [OB] at implants coated with amelogenin, indicating that bone formation andmaturation was accelerated by adding biological materials as a modification modality of implant surface
Conclusion: The present study concludes that coating of implants with amelogenin showed increment in osseointegration in short interval period