ABSTRACT
Objective: The aim of this study was to test the action of Porphyrin compounds, Tetraphenylporphine sulfonate [TPPS], 5,10,15,20-Tetrakis [4-sulfonatophenyl] porphyrinato Iron[III] Chloride [FeTPPS] and 5,10,15,20-Tetrakis [4-sulfonatophenyl] porphyrinato Iron[III] nitrosyl Chloride [FeNOTPPS], on Na[+], K[+] -ATPase of cell membrane of erythrocytes
Methods:Enzymatic assays, measuring the amount of inorganic phosphate produced, were used to estimate the activity of Na[+], K[+]-ATPase
Results:The results show that Porphyrin compounds exert an insulin-like effect on Na[+], K[+]-ATPase. They act by increasing the activity of the membrane-bound enzyme
Conclusion:All the three Porphyrin compounds increased the activity of erythrocyte Na[+], K[+]-ATPase. The exact mechanism of action of these compounds is not clear