ABSTRACT
This study was carried out on 100 seropositive rheumatoid patients' 86 females and 14 males with age ranging from 26- 70 years. A control group of normal healthy volunteers was taken for comparison. The patients were randomly classified into 5 groups each group comprised 20patients who received the recommended daily dose of a drug for 4 momths. The drugs given were voltaren for group I, feldene for group II prednisolone for group IIl a combination of voltaren and prednisolone for group IV and a combination of feldene and prednisolone for group V.IgG. IgA. IgM and B lymphocytes were increased before treatment at the end of treatment.lgM showed significant reduction in all the groups. B lymphocytes showed significant increase as compard to the control group at the end of treatment there was a significant decease. T-lymphocytes prercent showed highly significant decrease in all groups before treatment. This was followed by significant decrease at the end of treatment
ABSTRACT
We have studied 60 end stage renal disease patients, their age ranged between 2040 years. The sera of these patients were screened for the presence of lymphocytotoxic antidodies against peripheral blood lymphocytes of a random cell panel. Lymohocytotoxic antibodies were demonstrated in 25 patients [40%]. Those patient, with positive lymphocytotoxic antibodies were divided into groups. Those who undergoing maintenance heamodialysis and have recieved several blood transfusion [Group A].Those who have diagnosed for the first time and have not recieved blood [Group B]. The serum of those patients which were reactive with 30-100% of the above cell panel were then tested against autologous peripheral blood lymphocytes for detection of autoreactive lymphocytotoxic antibodies [AlcAs]. Autoreactive antibodies were detected in 50% of patients of group A and 18.8% of group B