Effect of sulphur compounds on the rat brain and liver monoamine oxidase-B

Rat brain and liver monoamine oxidase-B is inhibited when incubated with sulphur compounds [thiourea, sulphanilamide, sulphagunidine and sulphadiazine]. These compounds inhibit the monoamine oxidase-B enzyme reversibly with time and concentration dependent response. However, methionine has no effect on the enzyme. The values of K[m] and V[max] were determined from the lineweaver-Burk plot