ABSTRACT
Fungal sinusitis is a common disease in healthy young adults in our locality. It may destroy the skull base and invade the intracranial and intra-orbital compartments causing neurological and ocular manifestation. Combined neurosurgical and ENT approaches are mandatory for safe eradication of such skull base fungal infection. The objective of our study was to evaluate the results of combine neurosurgical and ENT surgical management for patients with fungal sinusitis with intracranial extension. We managed 10 cases with fungal sinusitis with intracranial extension. This included 7 females and 3 males. Four patients presented with -Ailatera1 proptosis, 2 with deterioration of level of consciousness due to meningitis, 2 with chronic headache, one with epilepsy and ow patient presented with trigeminal pain. All cases had long history of chronic headache and nasal obstruction. CT was done in all cases, MR in 8 patients, CT angiography and conventional cerebral angiography in one patient. Surgical intervention was decided according to the relation of the fungal granuloma to eloquent intracranial structures. End nasal approach alone wand used when the granuloma was not related to the optic nerve, internal carotid artery "ICA" or cavernous sinus [n=3]. Combined sub frontal and end nasal approach was used when the granuloma was closely related to one or more of these structures [n=5]. Transcranial approach alone was done for 2 patients with isolated sphenoid fungal sinusitis that was associated with a mycotic ICA aneurysm in one patient and with a temporal lobe abscess in the other. In addition, antifungal treatment was used for 8-12 weeks. Patients were followed up clinically and radiologically for 6-36 month period. The results of our study showed that one patient died two month post-operatively from fungal meningitis. No morbidity related to the operative procedures was recorded in the study group. Proptosis was completely corrected in the four cases. Follow-up CT showed eradication of the fungal granuloma in all patients. Histopathologically, fungal infection included mucormycosis and aspergillosis. From this study, we concluded that team ENT and neurosurgical work and early diagnosis are mandatory in the management of fungal sinusitis with intracranial extension in immune-competent patients. Surgical planning according to the relation of fungal granuloma to eloquent neurovascular structures is the corner stone for safe removal of granuloma