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1.
Indian J Biochem Biophys ; 2001 Dec; 38(6): 412-6
Article in English | IMSEAR | ID: sea-28496

ABSTRACT

The liquid membrane phenomenon in angiotensin converting enzyme (ACE) inhibitors namely, captopril and lisinopril has been studied. Hydraulic permeability data have been obtained to demonstrate the existence of the liquid membrane in series with a supporting membrane generated by the ACE inhibitors. Data on the transport of the relevant permeants in presence of the liquid membrane formed by ACE inhibitors indicate that liquid membrane phenomenon is likely to play a significant role in the action of ACE inhibitors.


Subject(s)
Angiotensin-Converting Enzyme Inhibitors/pharmacology , Captopril/pharmacology , Cellulose/analogs & derivatives , Lisinopril/pharmacology , Membrane Fluidity/drug effects , Membranes, Artificial , Permeability , Surface Properties
2.
Indian J Biochem Biophys ; 1991 Feb; 28(1): 34-9
Article in English | IMSEAR | ID: sea-28499

ABSTRACT

The liquid membrane phenomenon in the actions of digitalis glycosides (digitoxin, digoxin and ouabain) has been studied. Formation of liquid membranes, in series with a supporting membrane, by digitalis alone and by digitalis in association with lecithin and cholesterol has been demonstrated. The results obtained on the transport of relevant permeants, viz. sodium, potassium and calcium ions and dopamine, adrenaline, noradrenaline and serotonin, in the presence of the liquid membrane generated by digitalis in association with lecithin and cholesterol indicate that the liquid membrane barrier to transport may have a relevance with the biological actions of digitalis.


Subject(s)
Cholesterol/chemistry , Digitoxin/chemistry , Digoxin/chemistry , Membranes/metabolism , Micelles , Ouabain/chemistry , Permeability , Phosphatidylcholines/chemistry , Potassium/metabolism , Sodium/metabolism , Surface Properties
3.
Indian J Biochem Biophys ; 1989 Jun; 26(3): 172-7
Article in English | IMSEAR | ID: sea-29152

ABSTRACT

Modifications in the transport of relevant permeants to their respective sites of action due to the liquid membranes formed by prostaglandins in association with lecithin and cholesterol have been discussed in the light of biological actions of prostaglandins. It has been shown that the phenomenon of liquid membrane formation is likely to make a significant contribution to the biological actions.


Subject(s)
Alprostadil/physiology , Dinoprost/physiology , Membrane Fluidity/physiology , Membranes, Artificial , Permeability
4.
Indian J Biochem Biophys ; 1989 Apr; 26(2): 104-8
Article in English | IMSEAR | ID: sea-26732

ABSTRACT

The liquid membrane phenomenon in benzodiazepines has been studied. Transport of glycine, GA-BA, noradrenaline, dopamine and serotonin in the presence of the liquid membranes generated by the benzodiazepines in association with lecithin and cholesterol has been studied. The data indicate that modification in permeabilities in the presence of the liquid membranes is likely to make a significant contribution to several biological actions of the benzodiazepines.


Subject(s)
Benzodiazepines/pharmacology , Cell Membrane Permeability/drug effects , Membranes, Artificial , Solutions
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