ABSTRACT
Wet age-related macular degeneration and diabetic retinopathy are pathological consequences of vascular endothelial growth factor (VEGF) release as a reaction to deficiency of oxygen and nutrients in the macular cells. Conventional treatment modalities have been constrained by limited success. Convincing evidence exists that targeting VEGF signaling is a significant approach for the therapy of these ocular angiogenesis-dependent disorders. We have come a long way since the approval of the first angiogenesis inhibitors in medicine. The clinical use of these drugs has provided enormous tempo to clinical and pharmacological research. It has also significantly altered patient outcome and expectations. In the following brief, we will discuss the development and emergence of these drugs as well as the anticipated future course based on evidence.
Subject(s)
Angiogenesis Inhibitors/therapeutic use , Antibodies, Monoclonal/therapeutic use , Aptamers, Nucleotide/therapeutic use , Diabetic Retinopathy/complications , Humans , Macular Degeneration/drug therapy , Treatment Outcome , Vascular Endothelial Growth Factor A/antagonists & inhibitorsSubject(s)
Ethics, Medical , Humans , India , Physician-Patient Relations , Surveys and Questionnaires , Retrospective StudiesABSTRACT
Information technology has had a tremendous impact on the outlook of our professional lives. The Internet has revolutionised the speed of access to information with touch of a button. This article discusses the various aspects of information technology which are changing and enhancing our professional lives. It provides tips to enable the busy practising clinician to use the available resources effectively. Problems such as reliability of information on the web and how to assess the quality of such matter are also discussed.
Subject(s)
Humans , Information Systems/standards , Internet/trends , Ophthalmology/methods , Telemedicine/methodsSubject(s)
Aged , Anesthesia, Local/adverse effects , Anesthetics, Local/administration & dosage , Conjunctiva , Follow-Up Studies , Humans , Injections , Intraocular Pressure , Lens Subluxation/etiology , Male , Needlestick Injuries/etiology , Orbit , Sclera/injuries , Visual Acuity , Vitreous Hemorrhage/etiologyABSTRACT
Internet, e-mail, world wide web and the information superhighway have fast become part of the modern human vocabulary. How are we as ophthalmologists affected by this revolution and how can we utilise the enormous potential of this revolution? This article provides an overview of the practicalities and possibilities of this new medium.