ABSTRACT
This research study was conducted to investigate acute oral toxicity and analgesic activity of ethanol extract of P. domestica fruit by using tail flick analgesiometer at 300 and 500mg/kg doses in animal models. Acute oral toxicity results showed that crude extract is safe up to the dose of 5g/kg body weight of animals. The analgesic activity revealed that P. domestica extract at 500mg/kg dose possesses highest significant and prolonged analgesic activity in dose dependent manner as compared to standard and control groups. Aspirin 300mg/kg body weight was used as standard drug. Phytochemical analysis was also carried out which showed the presence of certain phytochemicals constituents in test drug that are responsible for analgesic activity. Therefore the results are justified