effect of high ceiling diuretic [lasix] on the periodontium of albino rats

This study was designed to investigate the effect of high dose of furosemide on the periodontium of albino rats. The animals received an intramascular injection equal to 1.6 ml of the ampul of furosemide [represents 80 mg of the drug] day after day for 8 weeks. The rats were sacrificed by cervical dislocation 2,4,6,8,10,12,14 and 16 weeks from the beginning of the experiment. The histopathological results revealed severe degenerative and destructive changes in the gingival tissues and the periodontal ligament as well as apparant bone resorption at the 8th week of the experiment, while cementum was more resistant to resorption than bone. However, such changes were only temporary and reversible

Salivary alpha-I-antitrypsin in marginal and juvenile periodontitis

The aim of the present study was to find out the relation betweenalpha-1-antitrypsin and the most destructive periodontal diseases, marginaland juvenile periodontitis. The results of the present study showed thatthere is a slight, but not significant, reduction of study alpha-1-antitrypsin in marginal periodontitis patients, when compared with reduction in the samesubstance in juvenile periodontitis group, which showed a statisticallysignificant reduction. It may be concluded that alpha-1-antitrypsin enzymemay be consumed through the process of progressive destruction or formed acomplex with other substances in saliva [e.g. IgA], or it could be due to aninnate salivary reduction in this enzyme

Early onset periodontitis and its possible relationship to diabetes mellitus

A great deal of controversy has existed concerning the role of diabetes Mellitus in periodontal disease; many clinical investigation have shown the diabetic conditions to be associated with an increased frequency and severity of periodontal tissue breakdown especially in young adults. Impaired neutrophil chemotaxis has also been reported in diabetic patients which may be another factor in decreased response to inflammation .Compromised neutrophil function is likely to contribute to the severity of periodontal disease as those with juvenile periodontitis, some forms of neutrophil dyscrasia such as cyclic neutropenia, agranulocytosis, Chediak - Higashi syndrome and also some insulin dependent diabetic patients. Some investigators reported that a greater incidence of juvenile periodontitis may be present among patients with genetic predisposition to diabetes mellitus as compared to a comparable population of subjects with no family history of diabetes. It was therefor the purpose of this investigation to study the relationship between early onset periodontitis and diabetes mellitus. Our results showed that early onset periodontitis subjects participating had abnormal glucose utilization. Moreover, data from the present study showed that 60 percent of cases presented a positive family history for diabetes. It also suggests that the genetic factors are important but are only predisposing and must interact with environmental influences if early onset periodontitis is to develop. Our observations of decreased level of procollagam type III may indicate decreased formation of collagen type III which is present around blood vessels and near the basement membrane of the gingiva. Thus the integrity of periodontal ligament and its capability to repair is affected in early onset periodontitis

Reversibility of Iatrogenic effect of furosemide on the rat submandibular salivary gland

This study was undertaken to investigate histologically the effect of multiple intramuscular injections of furosemide on the rat submandibular salivary gland. The animals were sacrificed by cervical dislocation 2,4,6 and 8 weeks after administration of the last dosage. The histo pathological results revealed severe degenerative changes in all structures of salivary gland after 2 weeks and the serous portions were more sensitive to furosemide than mucous acini or duct system. However, the degeneration proved to be temporary and reversible