ABSTRACT
In this study 46 patients' suffering from SLE and 39 control groups the patients divided into disease with remission [11] and in active state [35] with age below 20 year or above all patients had complete clinical examination together with laboratory investigation. In this study females [41] more affected than male [5] in a ratio 8.1 and at age onset from [9:35] with malar rash [38]' photosensitivity [29], alopecia [31], mucosal ulcers [I I], arthritis [3 I], sororities [lo], renal disease [25] hepatic disease [18] and CNS [6], for the haemogram findings, anemias [35], leucopenia [24], lymphopenia [22] and thrombocytopenia [8]. Auto antibodies showed ANA in [43], anti-ds DNA [dl], anti-RO [28] and antism [23] Patients. The value of anti-ds DNA, anti-RO and anti-SM were significantly higher in patients with activity than control and remission. Peripheral pattern of ANA by IF was found in activity while homogenous in remission. In this study there was a significantly increased frequency of HLA -DRBl*03 and significantly decrease frequency of HLA-DRBI *7 in SLE patients than control. The frequency of HLA-DRBI * 11, I3 increased in SLE patients than control also HLA-DRBI *3, 11 with age onset less than 20 year while HLA-DRBI* 13 in age more than 20 years old. Regarding HLA-DRBI gene association with different clinical and laboratory findings, positive association of different clinical signs, also between certain clinical signs of SLE and auto antibodies. This study suggested that the presence of HLA-DRBl*03 may predispose to SLE or its clinical manifestation, while the presence of HLA DRBI *07 may have a protective effect from SLE. Also the presence of HLA-DRBI *03 or 11 predispose to early SLE in age less than 20 year while HLA-DRBI *I3 to late SLE development at age more than 20 years old