Effect of inhaled corticosteroids on intraocular pressure in COPD patients

The extent to which inhaled glucocorticoids increase the risk of intraocular pressure elevation has been controversial. To assess such risk attributable to fluticasone an inhaled glucocorticoide used in asthma and COPD therapy. COPD pts. with FEV1 < 50% on spirometry were identified as candidates for treatment with inhaled corticosteroids, according to GOLD criteria. Patients were divided into 2 groups: Group 1: Received a diskus device containing 50 micro grams of salmeterol [as xinafoate] and 250 micro gram of fluticasone propionate. Group 2: Received the same diskus device but containing 500 micro grams of fluticasone propionate [high dose inhaled corticosteroids]. Both groups received treatment. For 12 weeks and their intraocular pressure was measured using Applanation Tonometry before and after treatment. No fluticasone treatment effect on the intraocular pressure was evident in both groups. No association with an increased intraocular pressure was observed in COPD pts treated with fluticasone propionate at daily doses ranging from 500-1000 micro grams for duration of 12 weeks

Correlation between intraocular lens design, material and posterior capsular opacification rate

To evaluate and to compare the rate of occurrence and degree of posterior capsular opacification [PCO] after small-incision cataract surgery and implantation of two different Intraocular lens [IOL] materials and designs over 6 months follow-up. Magrabi Eye and Ear Hospital, Jedda, KSA, New Dar Al-Shifa Hospital [NDASH], State of Kuwait, International Eye Hospital, Cairo, Egypt. 80 eyes were included in our study. All eyes underwent st and ardized phacoemulsification technique and were divided into 2 groups; Group [A]: 40 eyes implanted with silicone IOL [PhacoFlex, round edged design, Allergan] and Group [B]: 40 eyes implanted with acrylic IOL [Acrysof, sharp edged design, Alcon]. A st and ardized morphological mapping for evaluation of PCO was done 1, 3, and 6 months postoperatively. Nd:YAG capsulotomy rate was also reported. Acrysof group had lower PCO incidence than silicone group, [20% and 30% respectively]. The Nd: YAG capsulotomy rate was 12.5% in Acrysof group and 22.5% in silicone group. Eyes implanted with acrylic lOLs had lesser PCO incidence and subsequently lesser Nd: YAG capsulotomy incidence than those with silicone IOL