ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the oncologic safety of nipple-sparing mastectomy (NSM) for breast cancer patients based on current literature.</p><p><b>DATA SOURCES</b>A comprehensive literature search of Medline, Embase databases was conducted for studies published through March 2014.</p><p><b>STUDY SELECTION</b>Our search criteria included English-language studies that focused on NSM at nipple-areola complex (NAC) involvement, patient selection, and recurrence. Prophylaxis NSM, case series or reports that based on very small population were excluded. In the end, 42 studies concerning NSM and oncological safety were included into the review.</p><p><b>RESULTS</b>NSM is a surgical procedure that allows the preservation of the skin and NAC in breast cancer patients or in patients with prophylactic mastectomy. However, the oncologic safety and patient selection criteria associated with NSM are still under debate. The incidence of NAC involvement of breast cancer in recent studies ranges from 9.5% to 24.6%, which can be decreased through careful patient selection. Tumour-nipple distance, tumour size, lymph node involvement and molecular characteristics can be evaluated preoperatively by clinical examinations, imaging studies and biopsies to predict the risk of NAC involvement. Currently, there is no available standard protocol for surgical approaches to NSM or pathological examination of NSM specimens. The local recurrence (ranges from 0% to 24%) of NSM is not significantly higher than that of traditional mastectomy in selected patients based on long-term follow-up. The role of radiotherapy in NSM is still controversial and is not universally accepted.</p><p><b>CONCLUSIONS</b>NSM appears to be oncologically safe following careful patient selection and assessment of margins.</p>