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Rev. méd. Minas Gerais ; 7(1): 23-27, jan.-mar. 1997. tab
Article in Portuguese | LILACS | ID: lil-755246

ABSTRACT

A excitoxicidade relacionada ao neurotransmissor aminoácido glu- ta mato e ao seu receptor NMDA (n-metil-d-aspartato) consiste em um mecanismo de elevado potencial para explicar a fisiopatologia da esquizofrenia. Os neurolépticos atípicos clozapina e olanzapia têm potencial para proteger contra a neurotoxicidade gerada pelos antagonistas de NMDA.


Excitotocicity due to glutamate and its NMDA (N-methyl-D- aspartate) receptor are a possible mechanism for the physiopatholoy of schizophrenia. The atipical neuroleptic drugs clozapine and olanzapina present the potencial to protect against neu- rorocity caused by NMDA antagonists.


Subject(s)
Humans , Schizophrenia/physiopathology , Receptors, N-Methyl-D-Aspartate , Glutamic Acid
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