ABSTRACT
Background: Hyperlipidemia is the primary risk factor for coronary artery disease and subsequently leading to morbidity and mortality in adulthood. It is a well-known fact that coronary artery disease can initiate in the fetal stage itself. The present study was planned to analyse cord blood lipoproteins and apolipoproteins levels and its association with gender and birth weight.Methods: This cross-sectional study was conducted in the Department of Biochemistry, in collaboration with Department of Gynecology and Obstetrics at SKIMS Medical College and Hospital, Bemina, Srinagar. A total 200 pregnant women who delivered by normal vaginal delivery and caesarean section were included in the study. 10 ml of umbilical cord blood was collected in a plain vial from the placental end within five minutes of delivery and serum lipoprotein and Apo-lipoprotein levels were measured.Results: Out of 200 newborns102 were males and 98 were females. Statistically significant difference was seen in parameters Apo A1, Apo B, Atherogenic index (Apo B/Apo A1) and LDL between the genders rest of the parameters were statistically. Also 32 newborns (16.0%) had <2500, 152 (76.0%) new born had 2500-4000 and 16(8.0%) > 4000 grams birth weight. The mean lipoprotein and Apo-lipoprotein levels in these new born were compared between the groups. The mean serum levels of TC, TG, LDL and HDL were statistically significant (<0.05) between the three groups were as Apo A1, Apo B, Atherogenic index (Apo B/Apo A1) and VLDL was insignificant (>0.05) respectively.Conclusions: CVD being a leading cause of morbidity and mortality in the developing countries, early screening of the at risk babies i.e. low birth weight newborns using cord blood lipoproteins and apolipoproteins levels helps in primordial and primary prevention of diseases.
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Background: Inflammatory bowel disease usually presents with gastrointestinal stigmata of weight loss, anaemia, and rectal bleeding, but may exhibit prominent extra-intestinal manifestations also such as joint symptoms, skin signs and some other auto-immune manifestations. During the last few years many authors have reported serious complications of IBD manifesting in the Ear-Nose-Throat (ENT) and influencing disease morbidity. Methods: Twenty four patients with active ulcerative colitis (mean age 45 years) were recruited prospectively along with 24 healthy age- and sex-matched controls. Otoscopy, tympanometry and pure tone audiometry were performed. Otoscopy and tympanometry were normal in all patients and controls. Pure tone audiometry showed sensorineural hearing loss over all frequencies in patients with inflammatory bowel disease and compared with controls. The otologic data including age of onset, family history of otologic problems, exposure to noise and audiometric findings were also reviewed. Results: Out of 48 patients with a history of IBD, 24 had documented SNHL, 17 of these patients had a diagnosis of ulcerative colitis and 7 had Crohn’s disease. 22 patients had bilateral SNHL, and 2 patients had unilateral SNHL. Tinnitis were the most common associated aural complaint. Conclusion: Sensorineural hearing loss is very unusual finding, possibly of auto-immune aetiology. We recommend steroid or immunosuppressive therapy in such a patient. Evidence for an autoimmune basis for this condition is reviewed and the potential benefit of systemic corticosteroids emphasized.
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Introduction: Stature is considered as one of the important parameters for personal identification. So, Stature reconstruction is important as it provides forensic anthropological estimation of the height of a person in the living state which plays a vital role in the identification of individual remains. Aim: The aim of the present study was to investigate the association of hand length with height and to show if height could be predicted using hand lengthmeasurements in students of SKIMS Medical college. Methodology: The study of the anthropometric characteristics of 100 Medical College students of ages between 18-23 years of SKIMSMedical college, beminawith no obvious deformities or previous history of trauma to the spine or hand was undertaken. The study of these medical students, males (n=50) & females (n=50) was investigated. The anthropometric characteristics of their height and hand length were measured, analysed statistically for any significant difference, and correlation between the parameters studied. Results: The results show some significant differences between the anthropometric parameters, Pearson’s correlation analysis was used and showed a strong positive correlation, which means that high X variable scores go with high Y variable scores.(R is 0.8229) and it is significant. Results from the present study show that therewas a positive correlation between height and hand length indicating that height could be predicted using hand length. Conclusion: As age groups increase the mean length of hand also increase, so there is direct relation between length of hand and age groups. Definite proportion also exists between the height and hand length in an individual at all ages, irrespective of the sex. Height of an individual is 9 times the height of hand length. Thus we can predict height from hand length when it is difficult or not possible to measure height directly.
ABSTRACT
Background: Over the past three decades, the number of people with diabetes mellitus has more than doubled globally, making it one of the most important public health challenges to all nations. Therefore, the present study was undertaken to compare the levels of HbA1c, serum calcium, serum magnesium, serum phosphate, serum uric acid and microalbuminuria in patients with newly diagnosed type 2 diabetes mellitus with normal healthy individuals. Methods: This is a cross sectional study and was undertaken in the Department of Biochemistry, SKIMS-MC&H, Bemina, Srinagar. Total 300 subjects included in this study were divided into 2 groups. Group I: included 150 normal healthy individuals, who were in the age group 30-80 years, of either sex. Group II: included 150 newly diagnosed patients of Type 2 diabetes mellitus in the same age group. Fasting blood samples were drawn and investigated for serum calcium, magnesium, phosphorus, uric acid, blood sugar and HbA1c. 24-hours urine was taken for estimation of microalbuminuria, and these values were compared with those of normal healthy subjects. Means ± standard deviation were calculated and student t-test was applied to find out significance level. Results: Mean serum levels of FBS, HbA1c, calcium, magnesium, phosphate, uric acid were 89.71 ± 9.22, 4.68 ± 0.47, 9.61± 0.84, 2.23 ± 0.41, 3.45 ± 0.46, 4.21 ± 1.04 in controls (group-I) and 145.57 ± 76.61, 8.94 ± 2.38, 8.09 ± 0.18, 1.92 ± 0.27, 2.82 ± 0.68, 7.01 ± 0.27 in cases (group-II) respectively (<0.001). Microalbuminuria showed significant mean difference between cases and controls 35.01 ± 41.30 and 15.35 ± 2.60 (<0.001). Conclusion: There is decrease in serum calcium, magnesium and phosphate levels, all these plays an important role in the regulation of glucose level in the blood. Hence oral supplementation of all these ions other than diet is recommended. Increased serum uric acid and microalbuminuria was seen with reduced glucose tolerance hence early estimation of both the parameters should be done while monitoring case of Type-2 diabetes and thus will help to decrease the incidence of renal complications.
ABSTRACT
Background: Overcrowding, poor hygiene, socio-economic status, climate, lack of resources to avail medical facilities, poor medical awareness have their bearing on the incidence of hearing loss. The family of each hearing-impaired child has its own cultural, social, educational, and financial background, and its own special needs. The aim of this study is to determine the percentage of hearing impaired school going children in Ghaziabad city. Methods: The material for the present study were a representative sample constituting 1000 school children selected from various localities of Ghaziabad city within age group of 6-12 years. The children belonged to all the strata of society and children from both sexes were evaluated for hearing loss and its underlying etiological factors. Children were subjected to detailed ENT examination in our OPD. Results: In the present study sample the incidence of hearing loss is 9.3%. The maximum cases 60.22% belonged to the low socio-economic strata. A statistically significant difference of distribution by gender was noticed with a male preponderance (61.29%) as against 38.71% for females. The hearing loss in majority of cases was of a mild degree i.e., 26 to 45 dB (34.41%) of which majority of cases (87.10%) had conductive loss. Wax was the commonest cause of hearing loss (41.94%). CSOM was found in 21.50 % of all cases. Peak prevalence of hearing loss was found at 8 years of age, again declining after that from 20.43 % to 5.38 % by 12 years of age. Also it was observed that 59.14% children were living in crowded localities of city & 40.86% were living in non- crowded/open locality which is again statistically significant (P ≤0.05). Conclusion: The inferences drawn from the present study substantiates the view point of earlier workers that school screening is the most effective method of diagnosing deafness in school going children and should be extended to all schools in all the areas. Proper assessment and diagnosis of hearing loss in children at a very early age is important because an early diagnosis determines the efficacy of methods used for the correction of the hearing loss. Also early diagnosis of hearing impairment is a key to proper rehabilitation. The cases reporting to the hospital for treatment and rehabilitation can be regarded as the tip of the ice-berg and can have more management difficulties when compared to sub-clinical cases.