ABSTRACT
Objective: To evaluate the types, morphology, frequency and risk factors of breast carcinoma in modified radical mastectomy specimens
Design: Cross Sectional study
Place and Duration of Study: In Shaukat Khanum Laboratory Lahore, within 10 months from January 2012 to December 2012
Patients and Methods: By using non probability, convenient sampling technique 90 patients between 30-80 years, who underwent modified radical mastectomy, were recruited in the study from Lahore Medical University. Specimens were taken and fixed in 10% formalin. Gross and microscopic examination was done. To minimize the risk of diagnostic error slides were observed by two Histopathologists from Shaukat Khanum Laboratory Lahore
Results: 35.5% patients with breast carcinoma belonged to 4th to 5th decades, 50% patients [45/90] had carcinoma on right side, 66.6% [60/90] cases were infiltrating ductal carcinoma and 26.6 [24/90] cases were lobular type. Women with positive family history shows 33% [30/90] of breast carcinoma, of these samples 24% [22/90] females gives history of using oral contraceptive, whereas 22% [20/90] of them have positive history of smoking, 20% [n=18] had undergone radiation exposure
Conclusions: Highest frequency of breast cancer was found in 40-50 year old women. Ductal Carcinoma was the most common type. Factors highly associated with breast cancer in local population were found to be Positive family history, Oral Contraceptives and radiation exposure