ABSTRACT
An insight into the folate nutritional status of the population is important from a public health perspective. The protective effect of folate against neural tube defects (NTDs) is widely recognized. To assess the health and nutritional status, especially folate status, of vulnerable hill-tribe groups, a cross-sectional study was conducted on 197 schoolchildren and 136 women of childbearing age in Chaloem Phra Kiat District, Nan Province, Thailand. The nutritional status of the study group was investigated by dietary survey, and blood samples were taken to determine hematocrit, protein, and serum and red blood cell folate. Anthropometric measurements were taken to assess body size, composition and nutritional indexes. The health and nutritional status of the hill-tribe schoolchildren and women of childbearing age were found to be unacceptable, particularly inregard to folate status, which was indicated by low folate levels found in the blood samples, and in the intake of this micronutrient.
Subject(s)
Adolescent , Adult , Child , Child, Preschool , Female , Folic Acid/blood , Feeding Behavior/ethnology , Humans , Male , Middle Aged , Nutritional Status , Population Groups , Thailand/epidemiology , Waist-Hip RatioABSTRACT
To study the distribution and localization of oil-soluble arteether in experimental mice, we injected C14-labelled arteether (20 microCi/kg body weight) intramuscularly and measured radioactivity in the blood, kidney, and liver. The labelled arteether distributed and localized more to the kidney (819,180.4 +/- 34,134 dpm/cm3) than the liver (288,628.9 +/- 54,954 dpm/cm3) 4 hours post-injection. The main localization of labelled arteether was in the kidney cortex rather than the medulla (p < 0.05). However, the distribution of radioactivity was homogeneous in the liver. The terminal half-life of labelled arteether in the blood was 1.8 hours. The blood:kidney:liver ratio was 1:5:2. These findings show that labelled arteether was distributed quickly and localized in the cytoplasmic cortex of the kidney and homogeneously in the liver.
Subject(s)
Animals , Antimalarials/pharmacokinetics , Artemisinins/pharmacokinetics , Carbon Radioisotopes/diagnosis , Half-Life , Kidney/metabolism , Liver/metabolism , Male , Mice , Tissue DistributionABSTRACT
We measured the serum transcobalamin II in murine typhus- infected patients (n = 16) admitted to the Hospital for Tropical Diseases in 1996-1997, compared with healthy controls (n = 60). The results showed that the transcobalamin II (TCII) and total serum unsaturated vitaminB12 binding capacity (UBBC) in patients with murine typhus (2,126.5 pg/ml, range 1,262-4,568 and 3,771.5 pg/ml, range 1,576-6,763 pg/ml) were statistically significantly higher than normal subjects (987.5 pg/ml, range 678-2,000 pg/ml and 1,402 pg/ml, range 932-2,470 ml) (p<0.001). Serum TCII levels in patients (63%) were elevated during the febrile period and returned to normal post-treatment. These findings suggest that patients with murine typhus had stimulation of reticulo-endothelial system, spleen, mesenteric lymph nodes, liver and skin and then released TCII into the blood circulation. The elevation in TCII may be used for confirming a diagnosis of murine typhus.