ABSTRACT
@#Introduction: Poor sleep quality is frequently related to poor mental health and is a common medical disorder. It may differ by population, but limited studies have been done in Malaysia. This study was conducted to measure the prevalence of poor sleep quality among academic staff at Universiti Tunku Abdul Rahman (UTAR) Kampar Campus. Methods: In total, 344 randomly selected academic staff were approached to answer the Pittsburgh Sleep Quality Index (PSQI) questionnaire. Results: Unexpectedly, 42.7 % of them were affected by poor sleep quality (global PSQI score >5). The average actual sleep duration was recorded at 6.68 hours. Age and global PSQI scores were not significantly correlated. Female staff had poorer subjective sleep quality (P= 0.027). The elder age group (P= 0.012) and associate professors and professors (P= 0.006) consumed more sleep medications. Non-Ph.D. holders had poorer subjective sleep quality (P= 0.008) and sleep latency (P= 0.032) as well as global PSQI score (P= 0.045) compared to Ph.D. holders. Conclusion: Prevalence of poor sleep quality was higher than expected among academic staff. This may affect workplace functioning and burden the staff with more health issues related to poor sleep quality.
ABSTRACT
Objective: To evaluate antifungal and cytotoxic activities of four underutilised fruit species, i.e. Artocarpus altilis (breadfruit), Cynometra cauliflora (nam-nam), Mangifera pajang (M. pajang) (Bambangan) and Physalis minima (wild gooseberry). Methods: Extracts from the fresh flesh of Artocarpus altilis and Cynometra cauliflora, the flesh and kernel of M. pajang, and the whole fruit of Physalis minima were obtained by sequential extraction using hexane, chloroform, ethyl acetate, ethanol, methanol and distilled water. Each extract was assessed against six species of human fungal pathogens using a colourimetric broth microdilution method. The cytotoxicity was evaluated using African monkey kidney epithelial (Vero) cells. Results: All 30 extracts showed inhibitory activity against Cryptococcus neoformans. However, none of the extracts were active against Aspergillus fumigatus. The ethanol, methanol and water extracts from the kernel of M. pajang fruit showed the strongest activity against three species of Candida and Trichophyton interdigitale, with a minimum inhibitory concentration range of 0.001 - 0.630 mg/mL. The corresponding mean 50% cytotoxic concentrations for these three extracts were 358.7, 158.4 and 261.3 μg/mL, respectively against Vero cells. In contrast, the flesh of M. pajang fruit (hexane, chloroform and ethyl acetate extracts) showed statistically significant (P<0.001; ANOVA) strong toxicity against the cells, with 30.6, 13.5 and 22.2 μg/mL of mean values of 50% cytotoxic concentrations, respectively. Conclusions: The results suggest that the bioactivity of the kernel of M. pajang fruit is more selective towards fungi and thus is a potential source of new antifungal agents.