ABSTRACT
Theophylline pharmacokinetics before and after rifampicin administration was studied in 10 healthy volunteers. It was seen that Rifampicin significantly increased the volume of distribution of theophylline by 23.41% (p < 0.01) and its metabolic clearance by 47.65% (P < 0.05). This has got clinical significance in the treatment of patients of pulmonary tuberculosis with chronic obstructive airways disease where both the drugs may have to be given concurrently.
Subject(s)
Adult , Drug Synergism , Humans , Middle Aged , Rifampin/pharmacology , Theophylline/pharmacokineticsABSTRACT
The study has been conducted to find out the serum ADA levels in 120 patients with various pulmonary diseases which included patients with tubercular pleural effusion (n = 86), lung cancer (n = 10) and patients with non-tubercular pulmonary diseases like pneumonia, etc (n = 24). Twenty healthy individuals served as control subjects. The mean (+/- SD) of ADA activity was 23.38 (4.47), 7.29 (1.08), 12.71 (1.95) and 2.23 (1.00) units/litre in tuberculosis, malignancy, non-tubercular pulmonary diseases and healthy controls respectively with significant difference between each other (P less than 0.001). Patients with tuberculosis (100%) fall in 97% sensitivity range with a lower cut off limit at 17 units/litre ADA activity, while for malignancy and non-tubercular respiratory diseases, the sensitivity was 90% and 83% respectively. Within the sensitivity limits, the serum ADA activity can be used for the differential diagnosis of pulmonary diseases.
Subject(s)
Adenosine Deaminase/blood , Adolescent , Adult , Aged , Female , Humans , Lung Diseases/enzymology , Lung Neoplasms/enzymology , Male , Middle Aged , Tuberculosis, Pulmonary/enzymologyABSTRACT
A study of ventilatory function in tropical pulmonary eosinophilia was carried out. Seventy five cases and 75 healthy controls were studied. Four types of ventilatory patterns were observed-restrictive (52%), mixed (33%), obstructive (4%) and normal (10.6%).
Subject(s)
Female , Humans , India , Lung Diseases, Obstructive/diagnosis , Lung Volume Measurements , Male , Pulmonary Eosinophilia/diagnosisABSTRACT
Smoking habits of the medical students, both undergraduates and postgraduates, were evaluated by self-administering a predesigned proforma. 854 (66.05%) of the 1293 students responded, of whom, 30.7% of them were smokers. The number of smokers and the intensity of smoking increased with the advancement of their career at college. There were more smokers amongst the married and those with a history of smoking in their family. There was no systematic correlation between the socio-economic or rural/urban background and the smoking habit.