ABSTRACT
The purpose of this study was to examine the rate and clinico-Pathological characteristics of ovarian metastasis of endometrioid type endometrial cancer. A retrospective study of all patients with endometrioid type endometrial cancer was carried out during 1990-2009. Chi-square and Fisher's Exact tests were used to analyze all the variables. P = 0.05 was considered statistically significant. SPSS software [version 18], was used for statistical analysis of the data obtained. Two hundred and ten patients fulfilled the inclusion criteria. Only 17 [8%] cases were identified to have ovarian metastasis. Fisher's Exact test showed that the independent risk factors of ovarian metastasis in endometrial carcinoma included pathologic grading and depth of myometrial invasion [p<0.001 and p<0.02, respectively]. The risk of ovarian metastasis in the patients with well to moderately differentiated endometriod type endometrial cancer and myometrial invasion limited to less than one half of the myometrium is minimal. Therefore, it is possible to preserve ovaries in young women with early stage endometrioid type endometrial carcinoma, but it is better to remove and freeze ovarian tissue to save fertility without the recurrence risk of ovarian cancer
Subject(s)
Humans , Female , Ovarian Neoplasms/secondary , Neoplasm Metastasis , Endometrial Neoplasms/pathologyABSTRACT
Brucellosis is considered the leading zoonotic disease of the Middle East. The disease has a wide spectrum of clinical manifestations and can result in complications with severe morbidity. The aim of this study was to evaluate the frequency, distribution and characteristics of arthritis in Iranian children with brucellosis. A retrospective descriptive study conducted in a referral children center in Tehran from 1997 to 2005. Arthritis in children with brucellosis who were admitted to a specialized hospital was detected by clinical signs of the involved joint [s] and characteristics of joint fluid aspiration. Socio-demographic information was recorded. Of 96 patients diagnosed with brucellosis, 24 [25%] had Brucella arthritis 14 [58.3%] males and 10 [41.7%] females. Most common manifestations were fever in 21 patients [87.5%] and fatigue in 18 patients [75%]. Monoarthritis was recorded in 15 patients [62.5%] of the cases with involvement of the knee in 8 [45%] and hip in 5 [29%], the ankle in 2 [8%] patients while 9 [37.5%] patients suffered from polyarthritis. None of the patients had axial joints involvement. Seventy-five percent of the subjects [18 patients] were from urban areas and 66.7% [16 patients] had consumed un-pasteurized cheese. Recurrence was not seen in any of the 24 patients who received a combination of co-trimoxazole for 6 weeks and gentamicin for 5 days. Childhood brucellosis is a challenging disease in Iran that has serious complications like arthritis. Therefore all physicians who work in endemic areas should be familiar with this disease and consider the possibility of brucellosis in all children who present with arthritis and arthralgia