ABSTRACT
Obstetrical haemorrhage is the leading cause of maternal mortality, most commonly occurring in post partum period. Each year worldwide 530,000 die from causes related to pregnancy and childbirth. Post partum haemorrhage is a common and occasionally life threatening complication of labour and is mostly due to uterine atony, which is a failure of uterus to properly contract after the child is born. Consequently, bleeding from the blood vessels in the uterus is not controlled
Objectives: To compare the frequency of post partum haemorrhage in patients given tranexamic acid with active management of third stage of labour versus the control group given active management of third stage of labour alone
Methodology: A randomized controlled trial study carried out in the Department of Obstetrics and Gynaecology Unit-II, Sir Ganga Ram Hospital, Lahore. Total 420 patients were selected, 120 cases who received active management of third stage of labour with 1 gram injection of tranexamic acid and 120 controls who received active management alone
Results: Patients were divided in two groups with 210 patients in each group. As compared to active management of third stage of labour alone addition of tranexamic acid was associated with a significant reduction in frequency of post partum haemorrhage [PPH] and amount of blood loss. Frequency of PPH was 7.1% in control group and 2.4% in tranexamic acid group
Conclusion: It is concluded that adding tranexmic acid to the active management of third stage of labour is an efficient and safe method of reducing post partum haemorrhage