ABSTRACT
Objectives: Assessment of liver fibrosis by shear wave elastography in a patient of chronic liver disease associated infected by hepatitis B and C. Study Design: Observational Study. Place and Duration of Study: This study was conducted in the Department of Radiology JPMC Karachi from January to September 2015
Methodology: All the diagnosed cases of Chronic liver disease aged between 30 to 60 years and both gender associated with hepatitis B and C were selected. Patients using lipid-lowering drugs were excluded from this study. Assessment of liver fibrosis dividing into two groups, 1[st] group patients suffering liver disease since 2 years and 2[nd] group more than 2 years on SWE Qualitative and Quantitative analysis was done and staging of fibrosis according to METAVIR SCORE was done. Shear wave elastography and scoring are F0-F1 [5.3-7.1], F>2 [7.5-8.5] Grade 1-Mild, F>3 [9.5-13] Grade 2- Moderate and F>4 [13.1-18.8] Grade 3-Severe
Results: Out of the 80 patients, the majority was found to be male. 44[55%] males and 36[45%] females. Ratio between the male and female is 1.2:1. Mean age was found to be 44.57+7.54 years. Mostly Grade 2- Moderate changes observed in liver were 15[18.75%] of Hepatitis B Surface Antigen positive patients while 14[17.5%] Hepatitis C Virus Antibodies positive patients. Followed by Grade 1-Mild changes were 12[15%] of Hepatitis B+ve patients and 7[8.75%] Hepatitis C+ve positive patients. Grade 3-Severe were 9[11.25%] of Hepatitis B+ve patients and 4[5%] Hepatitis C+ve positive [Table No 2]. 4[5%] cases observed mild changes in both positive
Conclusion: Elastography techniques is noninvasive method can provide clinicians with innovative options as potential alternatives to liver biopsy for improving the quality of care for those patients with liver diseases