ABSTRACT
Wound healing is a complicated process that is influenced by many factors. Studies at molecular level on human and animal models have revealed several molecular changes related to the effect of diabetes on wound healing process. Increasing number of researches implicates the influence of mast cells on skin wounds healing. The present experimental study was conducted to compare systemic pentoxifylline administration on maturing process of mast cells during skin wound healing in diabetic and normoglycemic rats. In this experimental study, 48 wistar rats were divided into 2 groups of normoglycemic and diabetic and each group was divided into experimental and control. Experimental group received intraperitoneal [25 mg/kg twice a day] and control group received distilled water. The number of mast cells and their maturing process was evaluated by microscopically counting of the types of mast cells [types 1, 2, 3] by stereological methods on day 3 and 7 after surgery. In all experimental groups receiving pentoxifylline there were significant difference in the number of total mast cells, comparing normoglycemic groups [p<0.05] and also we found that in wound healing process pentoxifylline caused increasing the number of type 2 mast cells in all experimental groups [p<0.05]. In all pentoxifylline treated groups delay in converting type 2 into type 3 mast cell was seen. Pentoxifylline causes decreasing mast cell degranulation during wound healing process
ABSTRACT
An inflammatory bowel disease [IBD] is most common in highly industrialized Western countries but uncommon in less developed areas of the world where helminths are frequent. The hygiene hypothesis proposes that the recent increase in allergic and autoimmune diseases is due to modern highly hygienic life styles and medical conditions. Loss of routine exposure to parasitic helminths, as a result of increasing lifestyle-associated factors, may be one factor leading to the increased disease prevalence. In animal models and clinical trials of IBD, gastrointestinal nematodes colonization suppresses intestinal inflammation through multiple mechanisms including induction of innate and adaptive regulatory circuits. Studies using helminths like Trichuris suis or Necator americanus showed that these helminths are safe and may be effective therapeutic approaches for the control of IBD and other immune diseases. The aim of present review was to exploring the therapeutic use of helminths for the control of IBD