1.
Article
in English
| IMSEAR
| ID: sea-159149
ABSTRACT
Efficient and improved syntheses of 3,4-dihydropyrimidinones were reported using copper (II) acetylacetonate as catalyst. The reactants aldehydes, ẞ- ketoester and urea/thiourea were reacted very smoothly at acetonitrile reflux to obtain the corresponding condensation products in excellent yields and the reactions were completed within 3-6 hours of reaction time.
2.
Article
in English
| IMSEAR
| ID: sea-158157
ABSTRACT
The anti-histaminc drug cetirizine was synthesized in five linear steps with an overall yield of 50%. All the reactions were very clean and the isolation of products also very easy. Our synthetic strategy was applicable to large scale preparation of cetirizine.