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Acta cir. bras ; 32(3): 175-181, Mar. 2017. graf
Article in English | LILACS | ID: biblio-837692

ABSTRACT

Abstract Purpose: To examine a correlation of micro-PET images with photographic images of the digestive organs in abdominal sepsis model. Methods: Male Wistar rats weighing 265±18g were used. Abdominal sepsis was induced by ligature and cecal puncture. Micro-PET Images from abdominal cavity septic foci were obtained using 18-Fluoro-deoxyglucose, looking for a correlation with photographic images of abdominal cavity organs. Pearson's correlation test was used. Results: The mean standard uptake values (SUV) and lesion areas were 2.58±0.63SUVbwg/ml and 546.87±300.95mm2, respectively. There was a strong positive correlation between the two variables (r=0.863, p=0.137), which resulted in a coefficient of determination r2?0.75, meaning that 75% of SUV variation is explained by the lesion areas of digestive organs. Conclusion: Micro-PET allows high throughput assessment of lesion count and volume in pre-clinical rat model of CPL abdominal sepsis.


Subject(s)
Animals , Male , Sepsis/diagnostic imaging , Radiopharmaceuticals , Fluorodeoxyglucose F18 , Positron-Emission Tomography/methods , Intraabdominal Infections/diagnostic imaging , Time Factors , Reproducibility of Results , Rats, Wistar , Sepsis/pathology , Digestive System/pathology , Digestive System/diagnostic imaging , Disease Models, Animal , Photograph , Intraabdominal Infections/pathology
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