ABSTRACT
Background: Hyperthyroidism is associated with liver oxidative stress causing liver dysfunction in many hyperthyroid patients. The hepatoprotective effect of Satureja Khuzestanica Essential Oil [SKEO], as herbal origin antioxidant and anti-inflammatory agent on the hyperthyroidism induced hepatotoxicity and oxidative stress is investigated
Methods: Adult male sprague dawley rats were divided into categories of; control [group C], hyperthyroid [group H], hyperthyroid with olive oil [group H+O], hyperthyroid with vitamin E [group H+E], hyperthyroid with SKEO [group H+S], combination of hyperthyroid with vitamin E and SKEO [group H+S+E]. Hepatoprotective and antioxidant properties of SKEO with or without vitamin E in hyperthyroid rats were then investigated
Results: Serum Aspartate Transaminase [AST] and Alanine Transaminase [ALT] activities reduced significantly in H+O, H+E, H+S and H+S+E groups in comparison with hyperthyroid rats. Enzymes activities returned to normal in H+S+E group. Hepatic Malondialdehyde [MDA] was reduced in H+E, H+S and H+S+E groups in comparison with hyperthyroid rats. The most significant MDA reduction was in the H+S+E group. Glutathione Peroxidase [GPx] and Glutathione Reductase [GR] activities increased in H+E, H+S and H+S+E groups in comparison with group H. The largest increment in GPx and GR activities were in the H+S+E group. Glutathione level did not change in any group in comparison with the control group
Conclusion: Administration of SKEO has hepatoprotective effect in hyperthyroid rats and is more effective when used in combination with vitamin E