ABSTRACT
Osteoarthritis is the most prevalent chronic non-infective joint arthritis. In this present study, the effect of new herbal pomade [Marhame-Mafasel] on knee osteoarthritis was investigated in randomized trial. The objective of this study was to assess efficacy of Marahme-Mafasel pomade, which was consisted of several medic herbs like Arnebia euchroma and Martricaria chamomilla in primary osteoarthritis of the knee with non-compliance. The 2x2 crossover trial enrolled 42 osteoarthritis patients [Marhame-Mafasel versus placebo] in 2006. The instrument of data collection was Western Ontario and Mc Master Universities [WOMAC] LK3.1 standard questionnaires. We used conditional estimation to adjust non-compliance effect. The participants in each group were 21 patients. About 30 [71.4%] were female. The participants were between 40-76 years old. Positive analgesic effect of herbal pomade "Marhame-Mafasel" on knee osteoarthritis severity was considerable [P<0.01]. After adjusting results to compliance level, the estimators were sharper than crude results. Herbal joint pomade "Marhame-Mafasel" has significant positive analgesic effect on primary knee osteoarthritis