CD10 expression in ameloblastoma variants

Although benign ameloblastomas tend to behave aggressively with a high rate of recurrence. CD10 expression can help in predicting the behavior of these tumors. The aim of this study was to determine CD10 expression in variants of ameloblastomas. The data of thirty already diagnosed cases of ameloblastomas were taken. They were examined microscopically for selecting the sections with maximum epithelial content for immunohistochemical staining for CD10. A semi-quantitative scoring for determining the expression was used. In the present study, the follicular variant of ameloblastoma was the commonest [76.7%] followed by unicystic variant [13.3 %] and plexiform variant [10 %]. In the epithelial component CD10 expression was strongly positive in [76.2 %] and [80 %] showed moderate positivity. All the three cases of plexiform variant showed strong positivity. In unicystic variant [9.5%] were strongly positive and [20 %] were moderately positive. In the stromal component 50 % cases of follicular variant were strongly positive and 85.7 % were moderately positive. In the plexiform variant 25 % were strongly and 14.3 were moderately positive. In the unicystic variant strong CD10 positivity was seen in 25 % of cases. The present study concludes that all variants of ameloblastomas express CD10 positivity which may indicate their biological behavior

Estrogen receptor ? expression in salivary gland tumors

Immunohistochemical detection of Estrogen Receptors [ER] ? has demonstrated similarity between salivary glands and breast tumors. ER status is being routinely used for breast cancers in predicting response to therapy, suggesting their possible role in tumor management of SGTs. The aim of this study was to determine expression of estrogen receptor ? in salivary gland tumors in both genders and various age groups.The data of 57 already diagnosed cases of salivary gland tumors both benign and malignant were taken. They were examined microscopically for selecting the sections with maximum epithelial con-tent for Immunohistochemical staining for ER ?. Allred scoring system was used for assessing ER positivity.Among 57 cases of salivary gland tumors 34 [59.65%] were benign and 23 [40.35%] were malignant. The ER ? status was found positive in 31/57 [54.4%] of cases. Receptors positivity was present in 22 [65%] of benign and 9/23 [39%] of malignant tumors. The age range was 13-90 years. Maximum positivity for receptors [85.7%] was shown in the youngest age group [21-40 years] as compared to the oldest [above 60] which was 50.0%. Fourteen [56%] males and 17 [53.1%] females showed positivity for the ER expression.Present study concludes that salivary gland tumors, benign or malignant, may express estrogen receptor ? in any gender and age group irrespective of their histological and biological type