ABSTRACT
Oral lichen planus (OLP) is a chronic inflammatory mucosal disease of unknown etiology. Many studies have implicated the protective role of antioxidants in such diseases. The aim of this study was to compare salivary total antioxidant capacity (TAC and malondialdehyde (MDA) and antioxidant vitamin (vitamin s A, C and E) levels in patients with erosive OLP and healthy individuals. Thirty six patients with OLP (14 males, 22 females) and 36 control subjects (15 males, 21 females), matched for age and sex were enrolled in this case control study. The salivary levels of MDA, TAC, and antioxidant vitamin levels were measured in both case and control groups. The salivary level of MDA was significantly higher (p<0.001) in patients than in controls. In patients with OLP, the TAC of saliva was significantly lower than that in healthy subjects (p<0.001). Compared with controls, the levels of salivary antioxidant vitamins were significantly decreased in patients with OLP (p<0.001). In addition, a positive correlation was found between the decrease in the salivary amount of vitamin C and that in vitamin E in patients and controls. In addition to the lower salivary levels of antioxidant vitamins and the lower TAC, the higher level of MDA in patients with OLP suggests that free radicals and the resulting oxidative damage may be important in the pathogenesis of OLP lesions.
Subject(s)
Humans , Male , Antioxidants , Ascorbic Acid , Case-Control Studies , Free Radicals , Lichen Planus, Oral , Lipid Peroxidation , Malondialdehyde , Oxidative Stress , Saliva , Vitamin E , VitaminsABSTRACT
Oral lichen planus (OLP) is a chronic inflammatory mucosal disease of unknown etiology. Many studies have implicated the protective role of antioxidants in such diseases. The aim of this study was to compare salivary total antioxidant capacity (TAC and malondialdehyde (MDA) and antioxidant vitamin (vitamin s A, C and E) levels in patients with erosive OLP and healthy individuals. Thirty six patients with OLP (14 males, 22 females) and 36 control subjects (15 males, 21 females), matched for age and sex were enrolled in this case control study. The salivary levels of MDA, TAC, and antioxidant vitamin levels were measured in both case and control groups. The salivary level of MDA was significantly higher (p<0.001) in patients than in controls. In patients with OLP, the TAC of saliva was significantly lower than that in healthy subjects (p<0.001). Compared with controls, the levels of salivary antioxidant vitamins were significantly decreased in patients with OLP (p<0.001). In addition, a positive correlation was found between the decrease in the salivary amount of vitamin C and that in vitamin E in patients and controls. In addition to the lower salivary levels of antioxidant vitamins and the lower TAC, the higher level of MDA in patients with OLP suggests that free radicals and the resulting oxidative damage may be important in the pathogenesis of OLP lesions.
Subject(s)
Humans , Male , Antioxidants , Ascorbic Acid , Case-Control Studies , Free Radicals , Lichen Planus, Oral , Lipid Peroxidation , Malondialdehyde , Oxidative Stress , Saliva , Vitamin E , VitaminsABSTRACT
Mouth rinses beside the other methods have an important role in reducing dental caries. The aim of this study was in-vitro comparison of the anti-caries effect of polyphenol extract of green tea with 0.05% fluoride, 0.2% cholorhexidine and fluoridecholorhexidine. In this laboratory experimental study, 50 maxillary premolars were placed separately in tubes which contained cariogenic solution [streptococcus mutans, lactobacillus and 3 ml sucrose solution of 20%]. Each tube regarding the rinse solution was placed in 5 experimental groups [n=10] as follows: 1] normal saline, 2] 10% solution of green tea polyphenol extract, 3] 0.05% fluoride, 4] 0.2% cholorhexidine and 5] fluoride_cholorhexidine. Every 24 hours, the teeth were rinsed with 5 mL of the rinse. After 21 hours, the depth of decay was measured by polarized light microscope. Data were analyzed by SPSS V 13.0 software using Colmogrove Smirnove, One way ANOVA and Tukey tests. The mean and standard deviation of the depth of the caries in group 1 to 5 were 194 +/- 16.43, 175 +/- 17.94, 142 +/- 9.34, 155 +/- 13.27, and 144 +/- 8.57, respectively. One way ANOVA showed that there were significant differences between the groups [P<0.001]. Tukey test showed that although there was no significant difference in the depth of the caries between groups 1 and 2 [P=0.205], it was significantly less than groups 3 to 5 [P<0.001]. There were no significant differences between the depth of the caries in group 3, 4 and 5. According to the results of the current study, the anti-caries effect of flouride_cholorhexidine was the greatest between the groups. As the anti cariogenic effect of green tea was similar to that of normal saline and significantly less than fluoride or chlorhexidine, its use as a common mouth rinse needs more research