[Study of PAI-1 -675 4G/5G Polymorphism among patients with breast cancer from North West of Iran]

Background: Previous studies have shown the association of genetic factors such as PAI-1 4G/5G polymorphism with susceptibility to breast cancer patients. The aim of this study was to investigate the effect of this polymorphism in breast cancer patients from North West of Iran

Methods: 160 breast cancer patients and 160 healthy individuals were selected. Peripheral blood-DNA samples were taken and used for PCR amplification using the allele specific primers

Results: Based on molecular studies, all patients and control group were divided into three genotypes 4G/4G, 4G/5G and 5G/5G. Genotype distribution between patients [11.25%, 71.25% and 17.50%, respectively] and controls [10.62%, 71.87% and 17.50%, respectively]. Additionally, the frequencies of the 4G and 5G alleles between patients [46.87% and 53.12%, respectively] and control group [46.56% and 53.43%, respectively]

Conclusion: The genotypic and allelic frequencies of PAI-1 4G/5G polymorphism showed no significant difference between breast cancer patients and control individuals in this cohort

[ epidemiological study of breast cancer in eastern Azerbaijan of Iran during 2010-2012 and compared to previous 3 years [2007-2009]]

Background: Breast cancer is the most common malignancy among women. Survival rate depends on early detection and health care. The incidence rate of breast cancer varies by geographic region. The purpose of this study was to evaluate the epidemiology of breast cancer in Tabriz during two phases [2007-2009 and 2010-2012]

Methods: All breast pathologic records were studied in all hospitals in Tabriz. Malignant cases were classified according to the tumor-node-metastasis classification. Data were compared across the study. S t atistical analyses were performed using Excel [Microsoft Excel 2010] and SPSS [version 16.0]

Results: The results showed that the number of patients increased 52.76 percent in phase 2 compared to the first three years. A significant decrease in the diagnosis stage III was observed between phases 1 and 2 [P value=0.001, X2=21.721, CI=0.0001-0.001]

Conclusion: Our results confirmed that a down staging trend in breast cancer has occurred in Tabriz, despite the lack of formal screening programs. This may be due to an increasing awareness among Azeri women about the warning signs of breast cancer, enhanced available health services, and an improvement in socioeconomic status