Vitrectomy with or without radial optic neurotomy in management of central retinal vein occlusion [CRVO]

This study was curried out on 24 eyes [24 patients] having CRVO of recent onset. Patients were subjected to complete history taking as well as complete opthalmologifcal examination including best corrected visual acuity, anterior segment examination, intraocular pressure measurements and fundus biochmicroscopy. Fluorescein angiography and OCT SCAN were performed. They were divided into 2 groups, the first included 12 patients and underwent radial neuroomy, the second included 12 patients and underwent vitrectomy alone. The patients were examined postoperatively after one week, one month, 3 months and 6 months. In group I. The visual acuity improved in 7 eyes [58.3%], was stable in 3 eyes [25%] and worsened in 2 eyes [16.7%]. In vitrectomy group, the visual acuity improved in 5 eyes [41.7%], was stable in 4 eyes [33.3%] and worsened in 3 eyes [25%]. No correlation was found between the change in visual acuity and the age of the patient or the duration of CRVO. Macular and retinal hemorrhage completely disappeared in all eyes. Macular edema improved in 22 eyes of 24 patients, 11 patients in each group and worsened in 2 eyes [one in each group]. No post operative nonvascular complications were detected in any patient of 2 groups, none of the studied eyes showed persistence of the same degree of leakage present preoperatively, no intraoperative complications were encountered except for minimal bleeding in 3 eyes in group I and postoperative cataract occurred in 3 eyes, one in group 1 and 2 in group II

Distribution of IL-6 in human liver cirrhosis

In this study, sera and liver biopsies from 15 patients with clinically and pathologically diagnosed liver cirrhosis were taken. In addition, sera from seven liver biopsies from three healthy controls were used. The serum levels of interleukin-6 [IL-6] were measured using ELISA kits and the cellular distribution was investigated using immunohistochemistry. The results showed that serum IL-6 levels in cirrhotic patients [25.46 +/- 11.6 pg/ml] were significantly increased compared with the control group [12.14 +/- 6.6 pg/ml]. Immunohistochemically, in the control group, IL-6 was seen only in occasional sinusoidal cells. However, it was widely distributed in the cirrhotic liver. In the latter, it was mostly seen in the inflammatory cells infiltrating the liver but also expressed in the sinusoidal cells, Kupffer cells, vascular endothelial lining cells and hepatocytes. Upregulation of IL-6 in cirrhotic patients could be due to active synthesis or defective clearance by non- functioning hepatocytes