ABSTRACT
Stem cell therapy, an evolving, progressive field of therapeutics has shown several successes in areas where classic treatments failed to prevent or stop disability. Starting in 2009, twenty two sequential patients with progressive Multiple Sclerosis (MS) courses were treated with Autologous Bone Marrow Mononuclear stem cells (BM-MNSCs). The cells were given both intravenously and intrathecally. Using the Expanded Disability Status Scale (EDSS) score for evaluation, our data indicates that the majority of the patients benefited on the average one point on the scale. This paper adds to the body of evidence suggesting the safety and efficacy of autologous BM-MNSCs in the treatment of MS and awaits validation through larger, randomized studies.
Subject(s)
Humans , Bone Marrow , Multiple Sclerosis , Stem CellsABSTRACT
Prevent closure of an external intraventricular drainage with the use of heparin. A patient with intraventricular haemorrhage presented with repetitive closure of intraventricular drainage tube. A trial heparin infusion directly into the ventricle was attempted to prevent further closure of the catheter. The heparin used at a dose related of 340 units per 10 ml of intraventricular haematoma was effective in dissolving the clot and maintaining the external drainage patency. Thrombolytic therapy with intraventricular infusion of heparin may be life saving in intraventricular haemorrhage
Subject(s)
Humans , Female , Intracranial Hemorrhages/drug therapy , Intracranial Hemorrhages/mortality , Thrombolytic Therapy , Critical Care , Cerebral Ventricles , Hydrocephalus , Treatment OutcomeSubject(s)
Humans , Male , Female , Hydrocephalus , Cerebrospinal Fluid Shunts , Cranial Fossa, Posterior , CystsABSTRACT
During the last decade, technological advances for the treatment of osteoporotic vertebral compression fractures have provided quick pain reduction and prevention of further damage, through repair of kyphotic deformity. This entity is the major cause of additional vertebral deterioration and even in some cases can end in death. The substantial pain relief, reinstatement without inertia stiffness and restoration of kyphotic deformities are the major parameters of a successfiul treatment. Kyphoplasty offers successful treatment of this pathology