ABSTRACT
Aim:To evaluate the effects of intravenous clonidine (1mcg/kg) on hemodynamic responses, duration of seizure activity and recovery characteristics to modified ECT Materials and methods: This prospective randomized crossover clinical trial was performed on 30 patients aged 20–50 years with ASA I and II who were candidates for ECT. Prior to ECT, each patient received intravenous infusion of clonidine (1 mcg/kg) or a normal saline 10 minutes prior to induction. Baseline Heart rate, systolic, diastolic and mean arterial pressures were noted. The same parameters at 1, 2, 5,10,20,30,60 minutes and 2,4 hrs were noted. Motor Seizure duration and Time to recovery noted. Statistical analysis was done using paired students’ t’ test Results: Attenuation of maximum rise in the heart rate, systolic BP, diastolic BP and mean arterial pressure and increase in recovery time by intravenous clonidine (1 mcg/kg) was evident and statistically significant when compared with control group.