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1.
Article | IMSEAR | ID: sea-205794

ABSTRACT

Background: The batting performance is assessed by considering the batting average and strike rate of a batsman. With the induction of T-20 cricket matches, the strike rate of a batsman has gained much attention from coaches and team management. To increase the strike rate a batsman required to hit powerful shots for boundaries, which assist in making maximum scores at the minimum ball. Therefore, this investigation was planned to determine the effect of body size on the batting performance of cricket batsman. Methods: the literature for this study was selected for cricket coaching manual, cricket books, cricket batting videos, a biography of cricket batsmen, research articles. The academic documents were downloaded and shortlisted from Google Scholar, Research Gate, EBSCO, and ProQuest from 1990 to 2019. Results: The synthesized literature review concludes, stature, longer legs, longer arms, and lean body mass of a batsman show positive effects on the execution of powerful shots in cricket. Furthermore, the maximum strength of muscles assists a batsman to boost up the initial velocity of bat swing to accomplish the ball speed for a successful and powerful shot. Conclusions: Although stature and longer limbs of batsmen are associated with batting performance. On the other hand, the specific training would also enhance the capacity of cricket batsman for powerful shots in cricket. A future study was proposed to investigate the effect of training on the batting performance.

2.
Pakistan Journal of Pharmaceutical Sciences. 2018; 31 (4): 1399-1405
in English | IMEMR | ID: emr-198440

ABSTRACT

Six new diorganotin [IV] Schiff bases, [[CH3]2SnL] [I], [[C2H5]2SnL] [II], [[n-C4H9]2SnL] [III], [[C6H5]2SnL] [IV], [[CH2C6H5]2SnL] [V] and [[n-C8H17]2SnL] [VI] where L = N-[5-bromo-2 oxidobenzylidene]phenylacetohydrazide, were synthesized and characterized by elemental analysis, FT-IR, multinuclear NMR [1H, 13C] and UV-visible spectroscopy. Spectroscopic studies indicate coordination of ligand to the diorganotin [IV] moieties via ONO donor sites generating a pentacoordinated tin center. The synthesized compounds were tested in vitro for antibacterial activity against Klebsiella pneumonia, Salmonella typhimurium, Escherichia coli, Aeromonas, Staphylococcus aureus, Vibrio cholerae, Pseudomonas aeruginosa, Shigella flexneri, and in vitro antifungal activity against Aspergillus nigar, Fusarium solani, Aspergillus fumigatus and Alternaria species. All the compounds were also screened for antiurease activity

3.
Pakistan Journal of Pharmaceutical Sciences. 2016; 29 (2): 429-432
in English | IMEMR | ID: emr-176372

ABSTRACT

In the present research study 2-Aminoanthraquinone were scrutinized for their antimalarial and Xanthine oxidase inhibitor potential. It demonstrated marked concentration dependent antimalarial activity with maximum effect of 89.06% and with IC[50] of 34.17 micro M. Regarding Xanthine oxidase inhibitor activity, it evoked significant effect with 57.45% activity with IC[50] value of 81.57.19 micro M. In conclusion, 2-Aminoanthraquinone showed potent antimalarial and xanthine oxidase inhibitory activity


Subject(s)
Antimalarials , Xanthine Oxidase/antagonists & inhibitors , In Vitro Techniques
4.
Braz. j. microbiol ; 45(3): 985-993, July-Sept. 2014. mapas, tab
Article in English | LILACS | ID: lil-727030

ABSTRACT

In the present study, samples of rhizosphere and root nodules were collected from different areas of Pakistan to isolate plant growth promoting rhizobacteria. Identification of bacterial isolates was made by 16S rRNA gene sequence analysis and taxonomical confirmation on EzTaxon Server. The identified bacterial strains were belonged to 5 genera i.e. Ensifer, Bacillus, Pseudomona, Leclercia and Rhizobium. Phylogenetic analysis inferred from 16S rRNA gene sequences showed the evolutionary relationship of bacterial strains with the respective genera. Based on phylogenetic analysis, some candidate novel species were also identified. The bacterial strains were also characterized for morphological, physiological, biochemical tests and glucose dehydrogenase (gdh) gene that involved in the phosphate solublization using cofactor pyrroloquinolone quinone (PQQ). Seven rhizoshperic and 3 root nodulating stains are positive for gdh gene. Furthermore, this study confirms a novel association between microbes and their hosts like field grown crops, leguminous and non-leguminous plants. It was concluded that a diverse group of bacterial population exist in the rhizosphere and root nodules that might be useful in evaluating the mechanisms behind plant microbial interactions and strains QAU-63 and QAU-68 have sequence similarity of 97 and 95% which might be declared as novel after further taxonomic characterization.


Subject(s)
Bacteria/classification , Bacteria/isolation & purification , Plant Roots/microbiology , Soil Microbiology , Bacterial Typing Techniques , Bacteria/genetics , Cluster Analysis , Cytosol/chemistry , DNA, Bacterial/chemistry , DNA, Bacterial/genetics , DNA, Ribosomal/chemistry , DNA, Ribosomal/genetics , Genes , Glucose 1-Dehydrogenase/genetics , Molecular Sequence Data , Pakistan , Phylogeny , Plants , Quinones/analysis , Rhizosphere , /genetics , Sequence Analysis, DNA
5.
Braz. j. microbiol ; 45(2): 603-611, Apr.-June 2014. ilus, tab
Article in English | LILACS | ID: lil-723124

ABSTRACT

Glucose dehydrogenase (GDH; EC 1.1. 5.2) is the member of quinoproteins group that use the redox cofactor pyrroloquinoline quinoine, calcium ions and glucose as substrate for its activity. In present study, Leclercia sp. QAU-66, isolated from rhizosphere of Vigna mungo, was characterized for phosphate solubilization and the role of GDH in plant growth promotion of Phaseolus vulgaris. The strain QAU-66 had ability to solubilize phosphorus and significantly (p < 0.05) promoted the shoot and root lengths of Phaseolus vulgaris. The structural determination of GDH protein was carried out using bioinformatics tools like Pfam, InterProScan, I-TASSER and COFACTOR. These tools predicted the structural based functional homology of pyrroloquinoline quinone domains in GDH. GDH of Leclercia sp. QAU-66 is one of the main factor that involved in plant growth promotion and provides a solid background for further research in plant growth promoting activities.


Subject(s)
Enterobacteriaceae/enzymology , Enterobacteriaceae/physiology , Glucose 1-Dehydrogenase/genetics , Nerve Growth Factors , Phaseolus/growth & development , Phaseolus/microbiology , Cluster Analysis , Computational Biology , Cytosol/chemistry , DNA, Bacterial/chemistry , DNA, Bacterial/genetics , Enterobacteriaceae/genetics , Enterobacteriaceae/isolation & purification , Glucose 1-Dehydrogenase/chemistry , Models, Molecular , Molecular Sequence Data , Phylogeny , Protein Conformation , Protein Structure, Tertiary , Phosphorus/metabolism , Plant Roots/growth & development , Plant Shoots/growth & development , Quinones/analysis , Sequence Analysis, DNA , Sequence Homology
6.
Asian Pacific Journal of Tropical Biomedicine ; (12): S382-6, 2014.
Article in English | WPRIM | ID: wpr-343249

ABSTRACT

<p><b>OBJECTIVE</b>To evaluate pharmacologically the traditional use of Diospyros lotus as antipyretic and antinociceptive in various animal models.</p><p><b>METHODS</b>In vivo experimental models were used in this study. Antipyretic activity of extract/fractions was evaluated in brewer's yeast induced hyperthermic mice while antinociceptive activity was studied in acetic acid induced writhing test at 50 and 100 mg/kg i.p.</p><p><b>RESULTS</b>The crude extract strongly ameliorated the induced pyrexia during various assessment times. Upon fractionation, the antipyretic effects were strongly augmented by the chloroform and ethyl acetate fractions of the plant. However, hexane and butanol fractions were insignificant in their effect as antipyretic. The extract showed marked inhibition on the noxious simulation induced by post acetic acid injection. The effect was strongly supported by other fraction expect hexane.</p><p><b>CONCLUSIONS</b>In short, our study scientifically validated the traditional use of the plant as antipyretic.</p>

7.
Asian Pacific Journal of Tropical Biomedicine ; (12): 202-206, 2013.
Article in English | WPRIM | ID: wpr-312428

ABSTRACT

<p><b>OBJECTIVE</b>To study the screening of essential oils of Skimmia laureola leaves (SLO) for acute toxicity, antinociceptive, antipyretic and anticonvulsant activities in various animal models.</p><p><b>METHODS</b>SLO were extracted using modified Clevenger type apparatus. Acute toxicity test was used in mice to observe its safety level. Antinociceptive activity of SLO was evaluated in acetic acid induced writhing and hot plate tests. Yeast induced hyperthermic mice and pentylenetetrazole induced convulsive mice were used for the assessment of its antipyretic and anticonvulsant profile respectively.</p><p><b>RESULTS</b>Substantial safety was observed for SLO in acute toxicity test. SLO showed a high significant activity in acetic acid induced writhing test in a dose dependent manner with maximum pain attenuation of 68.48% at 200 mg/kg i.p. However, it did not produce any relief in thermal induced pain at test doses. When challenged against pyrexia evoked by yeast, SLO manifested marked amelioration in hyperthermic mice, dose dependently. Maximum anti-hyperthermic activity (75%) was observed at 200 mg/kg i.p. after 4 h of drug administration. Nevertheless, SLO had no effect on seizures control and mortality caused by pentylenetetrazole.</p><p><b>CONCLUSIONS</b>In vivo studies of SLO showed prominent antinociceptive and antipyretic activities with ample safety profile and thus provided pharmacological base for the traditional uses of the plant in various painful conditions and pyrexia. Additional detail studies are required to ascertain its clinical application.</p>


Subject(s)
Animals , Female , Male , Mice , Analgesics , Pharmacology , Anticonvulsants , Pharmacology , Antipyretics , Pharmacology , Body Temperature , Oils, Volatile , Pharmacology , Toxicity , Plant Leaves , Chemistry , Toxicity , Rutaceae , Chemistry , Toxicity Tests
8.
Asian Pacific Journal of Tropical Biomedicine ; (12): 280-283, 2013.
Article in English | WPRIM | ID: wpr-312415

ABSTRACT

<p><b>OBJECTIVE</b>To investigate the antipyretic and anticonvulsant activities of n-hexane fraction of Viola betonicifolia (V. betonicifolia).</p><p><b>METHODS</b>The antipyretic effect was scrutinized using brewer's yeast induced pyrexia and anticonvlsion effect was tested using pentylenetetrazol and strychnine induced convulsion in mice.</p><p><b>RESULTS</b>N-hexane fraction of V. betonicifolia demonstrated highly significant antipyretic activity during various assessment times (1-5 h) when challenged in yeast induced pyrexia test. The effect was in a dose dependent manner with maximum attenuation (82.50%) observed at 300 mg/kg i.p. When tested in pentylenetetrazol induced convulsion test, the 1st stage (Ear and facial twitching) and 2nd stage (Convulsive wave through the body) was 100% protected during 24 h at all the test doses (300, 400 and 500 mg/kg i.p.), while the latency time of remaining stages was significantly increased. The maximum effect was observed by n-hexane fraction of V. betonicifolia at 400 and 500 mg/kg i.p., as the latency time for generalized clonic-tonic seizure (5th stage) was increased up to 25.34 min. However, n-hexane fraction of V. betonicifolia had no protection in strychnine induced convulsion test.</p><p><b>CONCLUSIONS</b>In conclusion, phytopharmacological studies provide scientific foundation to the folk uses of the plant in the treatment of pyrexia and neurological disorders.</p>


Subject(s)
Animals , Female , Male , Mice , Anticonvulsants , Chemistry , Pharmacology , Antipyretics , Chemistry , Pharmacology , Disease Models, Animal , Fever , Drug Therapy , Hexanes , Chemistry , Plant Extracts , Chemistry , Pharmacology , Seizures , Drug Therapy , Viola , Chemistry
9.
Asian Pacific Journal of Tropical Biomedicine ; (12): 711-715, 2013.
Article in Chinese | WPRIM | ID: wpr-500505

ABSTRACT

Objective:To explore the medicinal importance of the stem of Desmodium elegans, methanolic extract, and its different solvent fractions were evaluated for brine shrimp lethality, insecticidal and phytotoxicity, antifungal, and antibacterial activities. Methods:The methanolic extract and its solvent fractions were tested for cytotoxic, phytotoxic, insecticidal, antifungal, and antibacterial effects using our previous published protocols. Results:The methanolic, DCM, ethyl acetate and n-butanol fractions exhibited insecticidal effect against Callosobruchus analis and Rhyzopertha dominic. The methanolic extract, n-hexane, DCM ethyl acetate and n-butanol showed 75, 85, 85, 65 and 5%phytotoxicity at the tested concentration of 500μg/mL respectively. The solvent fractions (DCM and ethyl acetate) were effective against F. solani (10%and 20%inhibition respectively). All the tested samples were devoid of cytotoxic and antibacterial effects. Conclusions:It was concluded that this plant can be practiced for control of weeds and insects.

10.
Asian Pacific Journal of Tropical Biomedicine ; (12): 280-283, 2013.
Article in Chinese | WPRIM | ID: wpr-500407

ABSTRACT

Objective: To investigate the antipyretic and anticonvulsant activities of n-hexane fraction of Viola betonicifolia (V. betonicifolia). Methods: The antipyretic effect was scrutinized using brewer’s yeast induced pyrexia and anticonvlsion effect was tested using pentylenetetrazol and strychnine induced convulsion in mice. Results: N-hexane fraction of V. betonicifolia demonstrated highly significant antipyretic activity during various assessment times (1-5 h) when challenged in yeast induced pyrexia test. The effect was in a dose dependent manner with maximum attenuation (82.50%) observed at 300 mg/kg i.p. When tested in pentylenetetrazol induced convulsion test, the 1st stage (Ear and facial twitching) and 2nd stage (Convulsive wave through the body) was 100% protected during 24 h at all the test doses (300, 400 and 500 mg/kg i.p.), while the latency time of remaining stages was significantly increased. The maximum effect was observed by n-hexane fraction of V. betonicifolia at 400 and 500 mg/kg i.p., as the latency time for generalized clonic-tonic seizure (5th stage) was increased up to 25.34 min. However, n-hexane fraction of V. betonicifolia had no protection in strychnine induced convulsion test. Conclusions:In conclusion, phytopharmacological studies provide scientific foundation to the folk uses of the plant in the treatment of pyrexia and neurological disorders.

11.
Pakistan Journal of Pharmaceutical Sciences. 2012; 25 (1): 51-58
in English | IMEMR | ID: emr-147961

ABSTRACT

In the present study four medicinal plants traditionally used in Pakistan for treatment of various ailments were evaluated for their heavy metals content, insecticidal, cytotoxic and phytotoxic actions. The metals like Cr, Cu, Zn, Mn, Ni, Pb, Fe and Co were determined in crude extract and various fractions. Soil samples were also tested for heavy metals to determine assimilation of any metal by the plant. Lead, chromium, copper, nickel and cobalt exceeded the permissible limit in most of the tested samples while the concentration of zinc, manganese and iron was within the permissible limit. Chloroform fraction from Achyranthes aspera and ethyl acetate fraction from Duchesnea indica showed significant phytotoxic activities. Crude extract and chloroform fraction from Xanthium strumarium showed insecticidal activity comparable to that of permethrin and thus could be a significant source of natural insecticide. The butanol fraction from X. strumarium showed significant cytotoxicity with LC[50] 1.9306 microg/ml, having mortality rate 93% at highest dose, while the crude extract from Valeriana wallichii showed 90% mortality rate [LC[50] 4.9730 microg/ml] at highest dose. However, the extracts from other plants were not effective against the brine shrimps tested

12.
Pakistan Journal of Pharmaceutical Sciences. 2012; 25 (4): 871-875
in English | IMEMR | ID: emr-148021

ABSTRACT

The current study was undertaken to estimate the concentration of micronutrients [Zn, Fe, Pb, Cu, Ni, Cd, Cr, Co, Sb and Mn], macronutrients [Na, Ca and K] and essential life nutrients [proteins, fats, carbohydrates and ascorbic acid] along with ash, fiber and moisture contents. Atomic absorption spectrophotometer was employed for the analysis of micronutrients while flame photometry for macronutrients. For proximate analysis [proteins, fats, carbohydrates, ash, fibers and moisture], Association of Official Analytical Chemists methods [AOAC] were used and titration method for ascorbic acid determination. It is evident from the results that the crude extract and its fractions accumulate significant concentrations of both micro and macro nutrients. The significant quantities of essential life nutrients like proteins, fats, carbohydrates and ascorbic acid along with ash, fiber and moisture contents were also found in extracts. It is concluded that the extracts of rhizomes accumulated significant quantities of life indispensible nutrients and validated the ethnobotanical uses of the plant as tonic and energizer

13.
Pakistan Journal of Pharmaceutical Sciences. 2012; 25 (2): 463-467
in English | IMEMR | ID: emr-128906

ABSTRACT

The current study was undertaken to evaluate the rhizomes of Polygonatum verticillatum against various pathogenic bacteria and fungi. Broad spectrum antibacterial activity was demonstrated by the crude extract of the plant and its subsequent solvent fractions; predominantly against Gram-negative bacteria. MICs of the extracts against Escherchia coli, Salmonella typhi and Shigella flexeneri were in the range of 1.5-40 micro g/ml, 03-06 micro g/ml and 03-40 micro g/ml, respectively. The only sensitive Gram-positive bacterium was Staphylococcus aureus with MICs in the range of 75-80 micro g/ml. The fungicidal activity was limited to Microsporum canis and Fusarium solani and the MICs were in the range of 350-360 micro g/mL and 190-290 micro g/ml respectively. The various fractions of rhizomes contained significant concentration of total flavonoidal and total phenolic contents that could be responsible for the current findings


Subject(s)
Anti-Infective Agents , Rhizome , Phenol , Anti-Bacterial Agents , Antifungal Agents , Plants, Medicinal , Plant Extracts
14.
Pakistan Journal of Pharmaceutical Sciences. 2012; 25 (3): 639-644
in English | IMEMR | ID: emr-144418

ABSTRACT

In the present study, Viola betonicifolia [whole plant] and solvent fractions obtained thereof were evaluated for various micronutrients such as lead, copper, chromium, iron, nickel, zinc, cadmium, cobalt and macronutrients such as sodium, potassium and calcium using atomic absorption spectrophotometer and flame photometry respectively. It was observed that cobalt and cadmium were not detectible in tested samples while remaining nutrients were present in variable concentrations. The concentrations of all metals were compared with the recommended limits for plants and the daily consumption of all the nutrients were calculated on the basis of dose [15 g/70 kg/day or 214 mg/Kg body weight] prescribed by hakims in their practice. The concentration of chromium was far beyond the recommended limits in almost all the samples. Proximate analysis was carried out in the powdered form of the plant. Viola betonicifolia appeared as a good source of life essential nutrients like fats [18.70%], proteins [15.70%], carbohydrates [21.42%], fiber [39.01%] and vitamin C [150 mg/100 g]. In conclusion, Viola betonicifolia is an excellent source of various micro and macronutrients for human being and can be used safely as a nutritional supplement


Subject(s)
Nutritive Value , Chromium/analysis , Copper/analysis , Iron/analysis , Lead/analysis , Metals/analysis , Micronutrients/analysis , Photometry
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