role of anticardiolipin and anti-B2 glycoprotein antibodies in clinical complication of lupus nephritis

Although there was confliction regarding the association of raised anticardiolipin antibodies [ACL] level with renal disease in systemic lupus erythematosus [SLE], the role of B2glycoprotein as a cofactor for ACL binding is established.The presence of ACL and anti-B2GPI may be directly involved in pathogenesis of antiphospholipid antibodies associated symptoms like recurrent fetal loss, thrombocytopenia and thrombosis. To study the possible association between some auto antibodies with the most common clinical complication of disease. The study was conducted on 25 patients with lupus nephritis, attended the renal clinic in specialized surgical hospital/ medical city /Baghdad, 25 lupus patients without nephritis and 25 healthy controls. Enzyme linked immunsorbant assay was used for detection for ACL, anti-B2GP. Although there was no significant difference in mean concentrations of ACL and anti- B2GP between lupus nephritis and without nephritis [P>0.05], lupus nephritis patients were more likely positive for ACL. Positivity of 100% For ACL and anti-_B2GPwere detected in thrombotic complication, in fetal loss complication patients more likely to be positive for ACL [75%], anti-B2GP [50%], in thrombocytopenia positivity of ACL and anti-B2GP [75%]. There was no association between anti-B2GP and renal disease and presence of both ACL and anti-B2GP carry higher risk for thrombosis and recurrent fetal loss

Evidence of correlation between some auto antibodies with complement component in lupus nephritis

lupus nephritis is a fatal complication of systemic lupus erythematosus [SLE], the serological hallmark of SLE is the presence of circulating autoantibodies directed against a wide variety of nuclear, cytoplasmic and plasma membrane antigens among which are anticardiolipin [ACL],anti B2 glycoprotein and anti-C1q antibodies, together with the consumption of complement component [C3 andC4] by immune complex mediated reaction. To shed light on the relations among these autoantibodies and with complement component in lupus nephritis patients. The study was conducted on 25 patients with lupus nephritis, attended the renal clinic in specialized surgical hospital! medical city /Baghdad, 25 lupus patients without nephritia and 25 healthy controls. Enzyme linked immunsorbant assay was used for detection for ACL, anti-B20P, anti-C1q, while single radial immundiffusion plates used for the estimation of C3and C4. Anticardiolipin antibodies correlated significantly with anti-B20P IgG and IgM [P<0.05], anti-C1q antibodies [P<0.01] respectively, also anti-C1q correlated with C3, C4 complement respectively