ABSTRACT
Objective: To evaluate side effects of Imatinib by patients of chronic myeloid leukemia and their influence on quality of life. Study Design: Descriptive and analytic study. Place and Duration of Study: The study was carried out at department of oncology CMH Rawalpindi, from Jan 2015 to Dec 2015
Material and Methods: The study was carried out at department of oncology CMH Rawalpindi from Jan 2015 to Dec 2015. Patients who had been using Imatinib orally for at least 6 months participated in the study. Patients under 18 years of age were excluded from the study. A questionnaire was developed to record adverse effects. This questionnaire included demographic details and quality of life issues like effects on their mood, daily life activities, work, walking and relationships
Results: Ninety two patients participated in the study. Mean age of the participants was 42.05 years [range 22 to 68 years], 52% were males. Among the study population eighty-seven percent had suffered from at least one adverse reaction. The most commonly complained adverse events were muscle cramps [67 out of 92, 72.8%]; fatigue [58 out of 92 63.04%], gastro intestinal upset [44 out of 92 47.82%] and skin rashes [30 out of 92 32.60%]. More than half of the patients felt that the adverse effect had a negative influence on their daily quality of life
Conclusion: Adverse drug effects were common among CML patients receiving Imatinib therapy. These adverse drug reactions had negative impact on patients' daily life
ABSTRACT
The present study was meant to investigate the types of error committed by dementia patients and normal subjects during recall under three different models. For this purpose three groups of subjects [N=81] were selected. Demented patients were referred from neurological and psychiatric wards of different hospitals of Peshawar. Mini Mental State Examination [MMSE] was used to determine the intensity of dementia. The score obtained on MMSE helped in the bifurcation of the patients into two groups i.e. severe and moderate dementia. Third group [control group] was matched on age, gender, education, and socio-economic status from normal population. Indigenous lists of visual clips based on relative, absolute and temporal coding of position were used to measure the types of error. One-way ANOVA was applied and the differences in types of errors among three positional models by patients with severe and moderate dementia and normal subjects were discussed. The present research highlights four types of error which are omission, intrusion, transposition and confusion