ABSTRACT
Objective: To determine the effect of different doses of male and female papaya leaf juice on prevention of carboplatin induced leucopenia in mice
Methods: A total of 55 Swiss albino mice were randomly divided into five groups [C,M10, M5, F10 and F5].Leucopenia was induced in all groups by a single intraperitoneal injection of carboplatin. Male papaya leaf juice was given to prevent leucopenia to groups M10 and M5 and female papaya leaf juice was given to F10 and F5. On days O, 7, 14 and 21 blood samples were collected by cardiac puncture for white blood cell count. Significance of different was calculated by one way ANOVA
Results: After carboplatin injection, white blood cell count decreased. Papaya leaf juice prevented fall in white blood cell count throughout the study period with p-value < 0.001. White blood cell counts were significantly high in all groups as compared to control on day 7 with no significant difference between gender and dose
Conclusion: Papaya leaf juice prevents leucoopenia induced by carboplatin in a dose dependent manner. There is no difference between male and female plants in this respect
ABSTRACT
Objective: To compare the in-vitro antifungal activity of Cymbopogon citratus and terbinafine by disc diffusion method against the selected clinical isolates of dermatophytosis"
Methods: This randomized controlled study comprised of 20 clinical isolates of superficial mycotic infections. Each of the 20 samples was inoculated in three petri dishes [total 60] on Sabouraud dextrose agar [SDA] medium. The prepared discs containing methanol extract of Cymbopogon citratus and terbinafine were placed on the inoculated plates. The diameter of clear zone around each disc in millimeters was measured after three days
Results: The antifungal activity of Cymbopogon citratus was 76%, 70%, 36% and 24% against Trichophyton rubrum, Trichophyton mentagrophyte, Microsporum canis and Microsporum audouinii respectively as compared to terbinafine [100%]
Conclusion: The Cymbopogon citratus is the potential candidate to be utilized for the treatment of superficial mycosis alternative to terbinafine
ABSTRACT
Objectives: To determine the effect of different doses of male and female papaya leaf juice on prevention of carboplatin induced anaemia in mice
Methods: A total of 55 Swiss albino mice were randomly divided into five groups [C,M10, M5, F10 and F5]. Anaemia was induced in all groups by a single intraperitoneal injection of carboplatin. Male papaya leaf juice was given to prevent of anaemia to groups M10 and M5 and female papaya leaf juice was given to F10 and F5. On days O, 7, 14 and 21 blood samples were collected by cardiac puncture for red blood cell count. Significance of different was calculated by one way ANOVA
Results: After carboplatin injection, RBC count decreased. Papaya leaf juice prevented fall in RBC count throughout the study period with p-value < 0.001. Difference between male and female papaya leaf juice was not significant while higher dose [10 ml/kg] produced significantly higher responses as compared to low dose [5 ml/kg]
Conclusion: Papaya leaf juice prevents anaemia induced by carboplatin in a dose dependent manner. There is no difference between male and female plants in this respect
ABSTRACT
There are no effective methods to treat thrombocytopenia once it occurs. Transfusions, growth factor injections and bone maiTow transplant have their limitations. So there is increased need for research of drugs that could prevent and treat thrombocytopenia. The objective the study to deter-mine the effect of different doses of male and female papaya leaf juice on prevention of carboplatin induced thrombocytopenia in mice. A total of 55 Swiss albino mice were randomly divided into five groups [C, M[10], M[5], F[10] and /y. Thrombocytopaenia was induced in all groups by a single intraperitoneal injection of carboplatin. Male papaya leaf juice was given to prevent of thrombocy topaenia to groups M[w] and M[5] and female papaya leaf juice was given to F[w] and F[5]. On days o, 7,14 and 21 blood samples were collected by cardiac puncture for platelet count. Significance of difference was calculated by one wayANOVA. After carboplatin injection, platelet count decreased. Papaya leaf juice prevented fall in platelet count throughout the study period with p-value < 0.001. Difference between male and female papaya leaf juice was not significant while higher dose [10 ml/kg] produced significantly higher responses as compared to low dose [5 ml/kg]. Papaya leaf juice prevents reversible thrombocytopaenia induced by carboplatin in a dose dependent manner. There is no difference between male and female plants in this respect