ABSTRACT
Introduction The aim of the present study was to determine the effect of exercise training and l-arginine supplementation on kidney and liver injury in rats with myocardial infarction (MI). Material and methods Four weeks after MI, 50 male wistar rats randomly divided into five followed groups: sham surgery without MI (Sham, n = 10), Sedentary-MI (Sed-MI, n = 10) 3: L-Arginine-MI (La-MI, n = 10) 4: Exercise training-MI (Ex-MI, n = 10) and 5: Exercise and L-arginine-MI (Ex + La-MI). Ex-MI and Ex + La-MI groups running on a treadmill for 10 weeks with moderate intensity. Rats in the L-arginine-treated groups drank water containing 4% L-arginine. Tissues oxidative stress and kidney and liver functional indices were measured after treatments. Result Urea as a kidney function indexes, increased in Sed-MI group in compared to sham group and decreased significantly in Ex-MI and Ex + La-MI groups. The level of catalase (CAT) and glutathione stimulating hormone (GSH) of kidney were significantly lower in the MI-groups compared with the Sham group and kidney Malondialdehyde (MDA) levels increased after MI and significantly decreased in response to aerobic training and L-arginine. As well as, aspartate aminotransferase (AST) and alanine aminotransferase (ALT) as liver injury indices, increased in MI-groups and decreased by training and L-arginine. In this regards, liver MDA and CAT respectively increased and decreased in MI-groups, but aerobic training and L-arginine increased liver glutathione per-oxidase (GPx) and decreased liver MDA. Conclusion These results demonstrated that kidney and liver function impaired 14 weeks after MI and aerobic training and L-arginine supplementation synergistically ameliorated kidneys and liver injury in myocardial infarction rats through oxidative stress reduction.
ABSTRACT
Plasma leptin, adiponectin [as theadipokines] and related obesity - HOMA index in the obese men are introduced as a predictive metabolic indicators for asthmatic individuals. However, under asthma conditions, role of cariometabolic variables interaction for altering clinical pulmonary indexes aren' t clear. In the present study, the relationship between plasmatic adiponectin to leptin ratio [adipo/lep] with respiratory capacities and HOMA in the chronic asthmatic males are investigated. Thirty nine obese males with mild to moderate asthma with an average age of 38 +/- 2.6 ys and BMI 31.4 +/- 1.06 kg/m[2] voluntarly participated in this study. Baseline plasmatic leptin, adiponetin, insulin and glucose levels were determined after 10-12 hours fasting overnight. FEV1/FVC, PEF% and FEF25%-75% were determined by standard method. A pearson correlation test was used to analyse data. There were no significant correlation between WHR, BMI with metabolic risk factors [P>0.05]. Relationship markedly observed among HOMA with adipo/ lep ratio and leptin levels respectively [P<0.05], Also a marked negative correlation between adipokine ratio and leptin level was obtained [P<0.05]. From view of respiratory efficiency, FVC% and FEV1/ FVC were maingly corrected with baseline leptin and adiponectin levels [P<0.05]. Inconclusion, it seems that adipo/lep ratio biomarker plays as a clinical diagnosis index for HOMA index than baseline leptin or adiponectin levels. However, these findings showed that FEV1/FVC and adipo/lept ratios are accounted as valuable indicators for evaluating the obesity syndrome and pulmonary efficiency in the asthma disease