ABSTRACT
Objectives: To assess the association of raised serum liver enzyme [ALT] with type 2 diabetic subjects
Methods: This retrospective data was accessed at Baqai Institute of Diabetology and Endocrinology [BIDE] from January 2005 to May 2016. A total of 1966 subjects with type 2 diabetes were included in the study. Subjects were divided into two groups; in group A 1284 subjects had ALT within the normal range [ALT >/= 35iu/l] and in Group-B 682 subjects had elevated ALT [ALT>35iu/l]. Details of demographics, anthropometric measurements and biochemical results at baseline were extracted from the health management system of BIDE. Data analysis was conducted on Statistical Package for Social Sciences [SPSS] version 20
Results: Out of 1966 type 2 diabetic subjects 1284 [65.4%] were observed with normal value of ALT [35]. Overall mean age of subjects was 54.66 +/- +/- 10.98 years and mean BMI was 27.34 +/- +/- 5.99 kg/m[2]. Significant difference was observed between the groups in age [if ALT>35], gender [more likely to be male] and triglyceride [higher if ALT>35].Whereas no significant difference was found between the groups in HbA1c, cholesterol, HDL and LDL
Conclusion: High frequency of elevated ALT suggests the association of liver disease with type 2 diabetes. The type 2 diabetic subjects need to be routinely screened and further studies to assess the possible associations with NAFLD and insulin resistance are required to further clarify the disease process