ABSTRACT
Objectives: Prolidase plays a vital role in collagen turnover, matrix remodeling, and cell growth. We aimed to evaluate the association between treatment with chorionic gonadotropin and infertility and erectile dysfunction by investigating
tissue prolidase activity, oxidative stress, and levels of antioxidant enzymes
Materials and Methods: The 16 male Wistar albino rats used in this study were randomly divided into 2 groups: rats treated with human chorionic gonadotropin [hCG] and control rats [n = 8 in each group]. The rats in the hCG group were subcutaneously injected with 50 IU hCG daily for 15 days, while the rats in the control group were subcutaneously injected isotonic saline. All of the rats were sacrificed by a lethal overdose of sodium pentobarbital at the first month after hCG administration. Prolidase activity and levels of malonyl aldehyde, glutathione reductase, superoxide dismutase [SOD], glutathione peroxidase [GSH-Px], and catalase [CAT] were estimated in the testicular and penile tissue. The testicles and penis were transversely dissected and placed in formalin
Results: Levels of prolidase and malonyl aldehyde in the testicular and penile tissues were significantly higher in the hCG group than in the control group [p < 0.001], while levels of glutathione reductase, SOD, GSH-Px, and CAT were significantly lower in the hCG group than in the control group [p < 0.001]
Conclusions: In this study, we observed that treatment with hCG increased prolidase activity and oxidative stress and decreased the antioxidant capacity of penile and testicular tissues; therefore, this may affect fertility and erectile function
ABSTRACT
To evaluate the efficacy and reliability of ureteroscopic pneumatic lithoripsy [URSPL] in patients with ureter calculi. A total of 612 patients who were treated with URS-PL in Medical school of Yuzuncu Yil University, Van State Hospital and Bingol State Hospital in the period between April 2005-May 2010 were studied. Diagnoses of ureter stones were made with intravenous pyelography [IVP] or computerize tomography [CT]. Ureteral balloon dilation was not performed on any patient. On the post-operative 1[st], 7[th] and 21[st] days, control direct urinary system graphic [DUSG] was taken. The rates of stone free and complication were analyzed with the ki-kare test. P < 0.05 was accepted as significant. The mean age of the patients was 39 +/- 10 [18-75]. There were 417 males [68.13%] and 195 females [31.86%]. The mean volume of calculi in patients was 10.1 +/- 2.3 mm. Of these patients, 121 had proximal ureter stone, 169 medial ureter stones and 322 had distal ureter stones. In the first session of URS-PL, the calculi of 96 patients in proximal ureter [80%], those of 143 patients in medial ureter [85%] and those of 305 patients [95%] in distal ureter were cracked successfully. The mean stone free rate was 92.4% [79.4% in upper ureter, 94.1% in middle ureter and 93.7% in distal ureter [P < 0.05]. Overall complication rate was 7.6% [7.7% in distal ureter, 3.9% in middle ureter and 11.8% in proximal ureter] [P>0.05]. Most common peroperative complications of the procedure were ureteral perforation 4,2% [n=26], infection 2.2% [n=14], and mucosal laceration 1.9% [n=12]. The most common late complication was ureteral stricture in 1.3% [n=8] of patients. Although URS-PL is a commonly used application for the treatment of patients with proximal and middle ureter stones, its common usage could also be extended to patients with distal ureter stones in the first stage of treatment, and it could be considered as an efficient and reliable procedure