ABSTRACT
Background and Objectives: Rheumatoid arthritis [RA] is an autoimmune disease that inflammatory mediators has an important role in its pathogenesis and leads to bone and joints destruction. This inflammatory status can be effected by different factors such as genetic, dietary intakes and hormonal factors. However, the influence of anthropometric on the severity of RA and inflammatory markers is still debatable
Material and Methods: The current study was done on a group of patients with documented RA who were under regular visit in our university hospital outpatients clinic from the start until the end of 2012. Based on DAS-28 criteria disease activity was assessed by a rheumatology specialist. Anthropometric measurements included body mass index [BMI], Waist to hip ratio [WHR],Waist to Height Ratio [WHtR] all were measured serum levels of highly sensetive cpp IL-6 and MMP-3, were measured in fasting serum samples
Results: There was a Positive correlation between obesity [body mass index and waist to height ratio] and disease activity score and serum levels of hsCRP [P <0.05]. There was no significant correlation between obesity with serum levels of MMP-3 and IL-6 [P > 0.05]
Conclusion: Present study indicates a significant direct correlation between obesity and disease activity and systemic inflammation marker [hscRP]. In RA thus, control of weight could be a very important strategy for maintenance remission in rheumatoid arthritis
ABSTRACT
BACKGROUND/OBJECTIVES: Rheumatoid arthritis (RA) is associated with an excess mortality from cardiovascular disease which is likely attributed to an atherogenic lipid profile. Among nutritional factors vitamin K has been recently focused as a pivotal nutrient in improvement of lipid related markers. Thus, this study was designed to determine the effects of vitamin K on lipid profile in this disease. SUBJECTS/METHODS: Fifty eight patients with definitive RA were participated in the present double blind placebo controlled study. They were randomly allocated into two groups to receive vitamin K1 as phylloquinone [10 mg/day] (n = 30) or placebo pills (n = 28), for eight weeks. In order to control the effects of probable confounders dietary intakes, anthropometric measurements including weight and height, clinical status using disease activity score-28 (DAS-28), physical activity and anxiety status were evaluated at baseline. Moreover, serum levels of lipid related markers including total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) and triglyceride (TG) were measured at baseline and at the end of intervention. RESULTS: There were no significant differences between the two groups regarding any of the baseline characteristics. After adjusting for some relevant confounders, in comparison between two groups, we observed no significant changes in lipid related markers at the end of intervention. Also, there was no significant difference between before and after intervention values within groups (P > 0.05). CONCLUSIONS: Function of vitamin K1 in lipid profile modification remains still controversial. This study showed that vitamin K1 has no effect on lipid profile in women with rheumatoid arthritis. Further studies with a longer follow-up are required to determine the effects of vitamin K on atherogenic lipid profile.
Subject(s)
Female , Humans , Anxiety , Arthritis, Rheumatoid , Cardiovascular Diseases , Cholesterol , Lipoproteins , Mortality , Motor Activity , Triglycerides , Vitamin K , Vitamin K 1ABSTRACT
BACKGROUND/OBJECTIVES: Rheumatoid arthritis (RA) is associated with an excess mortality from cardiovascular disease which is likely attributed to an atherogenic lipid profile. Among nutritional factors vitamin K has been recently focused as a pivotal nutrient in improvement of lipid related markers. Thus, this study was designed to determine the effects of vitamin K on lipid profile in this disease. SUBJECTS/METHODS: Fifty eight patients with definitive RA were participated in the present double blind placebo controlled study. They were randomly allocated into two groups to receive vitamin K1 as phylloquinone [10 mg/day] (n = 30) or placebo pills (n = 28), for eight weeks. In order to control the effects of probable confounders dietary intakes, anthropometric measurements including weight and height, clinical status using disease activity score-28 (DAS-28), physical activity and anxiety status were evaluated at baseline. Moreover, serum levels of lipid related markers including total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) and triglyceride (TG) were measured at baseline and at the end of intervention. RESULTS: There were no significant differences between the two groups regarding any of the baseline characteristics. After adjusting for some relevant confounders, in comparison between two groups, we observed no significant changes in lipid related markers at the end of intervention. Also, there was no significant difference between before and after intervention values within groups (P > 0.05). CONCLUSIONS: Function of vitamin K1 in lipid profile modification remains still controversial. This study showed that vitamin K1 has no effect on lipid profile in women with rheumatoid arthritis. Further studies with a longer follow-up are required to determine the effects of vitamin K on atherogenic lipid profile.