ABSTRACT
The present research was made to investigate the potential hypolipidemic effect of Ixora coccinea. Hypolipidemic activity is screened by inducing hyperlipidemia with the help of atherogenic diet in wistar albino rats and serum levels of biochemical parameters such as total cholesterol, triglycerides, LDL, VLDL and HDL cholesterol were determined. Atherogenic index shows the measure of the atherogenic potential of the drugs. Ethanol extract showed significant (p< 0.05) hypolipidemic effect by lowering the serum levels of biochemical parameters such as significant reduction in the level of serum cholesterol, triglyceride, LDL, VLDL and HDL level which was similar to the standard drug Atorvastatin. Ethanol extract exhibited significant atherogenic index and percentage protection against hyperlipidemia. Preliminary phytochemical analysis revealed the presence of phytoconstituents such as alkaloids, tannins, flavonoids, carbohydrates, protein and amino acids and reducing sugars which is further confirmed by HPTLC (high performande thin layer chromatography). The overall experimental results suggests that the biologically active constituents such as flavonoids, alkaloids, tannins and glycosides in the ethanol extract, of Ixora coccinea, may be responsible for the significant hypolipidemic activity and the results justify the use of Ixora coccinea as a significant hypolipidemic agent.