ABSTRACT
Background: acute kidney injury [AKI] is rapid decrease of renal function. AKI has been resulted in significant morbidity and mortality. The term RIFLE consist of risk, injury, failure, loss, and end-stage renal disease. A modified version of this criteria pRIFLE is used in pediatric population with AKI, for the severity assessment and its outcome. Therefore early intervention can be made. This study helps to make recommendations based on pRIFLE criteria for severity and outcome
Objectives: to determine severity and outcome of AKI in pediatric population using pediatric RIFLE criteria
Study design, settings and duration: it was a descriptive case series carried out in departments of Pediatric ICU and pediatric nephrology unit at National Institute of Child Health [NICH], Karachi from August 2010 to March 2011
Patients and Methods: total ninety seven children with acute kidney injury [AKI] were included in this study. Schwartz equation was applied for calculation of estimated glomerular filtration rate [eGFR] and severity of AKI was assessed using pRIFLE criteria at presentation andt then on daily basis till discharge. Outcome was labeled as death or alive. Data entered and analyzed by using SPSS version 19.0
Results: the pediatric RIFLE identified those at risk, injury, and failure in 16 [16.5%], 25 [25.8%], and 56 [57.7%] patients respectively. Outcome in term of mortality was observed in 11.3% cases. There was 6.3% death in those at risk, 17.9% [10/56] in those with failure and no significant in injury
Conclusion: there are significant number of patients in renal failure due to AKI, this implies lack of early detection of AKI and delayed referral to the pediatric tertiary care hospital so "pRIFLE criteria" can be widely used by all pediatricians for early detection of children with AKI in risk category so that early interventions may halt the progression of AKI to failure