ABSTRACT
Abstract: Psoriasis is a chronic inflammatory disease that affects 1.3% of the Brazilian population. The most common clinical manifestations are erythematous, scaling lesions that affect both genders and can occur on any anatomical site, preferentially involving the knees, elbows, scalp and genitals. Besides the impact on the quality of life, the systemic nature of the disease makes psoriasis an independent risk factor for cardiovascular disease, especially in young patients with severe disease. By an initiative of the Brazilian Society of Dermatology, dermatologists with renowned clinical experience in the management of psoriasis were invited to form a work group that, in a partnership with the Brazilian Medical Association, dedicated themselves to create the Plaque Psoriasis Diagnostic and Treatment Guidelines. The relevant issues for the diagnosis (evaluation of severity and comorbidities) and treatment of plaque psoriasis were defined. The issues generated a search strategy in the Medline-PubMed database up to July 2018. Subsequently, the answers to the questions of the recommendations were devised, and each reference selected presented the respective level of recommendation and strength of scientific evidence. The final recommendations for making up the final text were worded by the coordinators.
Subject(s)
Humans , Male , Female , Psoriasis/diagnosis , Psoriasis/therapy , Phototherapy/methods , Psoriasis/epidemiology , Societies, Medical , Time Factors , Vitamin D/analysis , Severity of Illness Index , Brazil , Comorbidity , Anthralin/therapeutic use , Methotrexate/therapeutic use , Cyclosporine/therapeutic use , Adrenal Cortex Hormones/therapeutic use , Dermatologic Agents/therapeutic use , Dermatology , Drug Combinations , Calcineurin Inhibitors/therapeutic use , Antibodies, Monoclonal/therapeutic useABSTRACT
Lúpus eritematoso discoide é uma desordem autoimune benigna da pele e representa a forma clínica mais comum de lúpus eritematoso cutâneo. A apresentação do lúpus eritematoso discoide com acometimento palpebral exclusivo, como neste caso, é extremamente rara, o que dificulta o diagnóstico precoce da doença. O desconhecimento dessa apresentação de lúpus e o consequente retardo do seu diagnóstico podem contribuir com a progressão da doença e resultar em cicatrizes inestéticas, o que pode prejudicar a função palpebral.
ABSTRACT
A doença de Darier é genodermatose autossômica dominante, porém, casos sem história familiar säo comuns. Caracteriza-se por pápulas ceratósicas, principalmente na parte superior do tronco e no couro cabeludo, ceratoses punctatas palmares e distrofia ungeal. Os autores relatam um caso de doença de Darier com extensas lesöes cutâneas, alteraçöes ungeais e lesöoes na mucosa oral, que säo raras. Realizou-se exame histopatológico em duas lesöes, uma na regiäo dorsal e outra na mucosa oral. O paciente foi tratado com etretinato na dose de 1mg/kg/dia (50mg/dia) durante um mês, com excelente resultado. Inclui-se revisäo da literatura.