Effect of some plants as functional food supplement on kidney function and structure in experimentally hyperuricemic rats

Hyperuricemia is associated with renal insufficiency and commonly used as a useful early biomarker for chronic kidney diseases. Celery leaves contain a valuable volatile oil and an organic substance called apiol. Celery leaves, chicory and barley are known to have beneficed effect for humans in health and disease. This work was carried out to investigate the effect of dietary fiber supplementation with celery, chicory and barley, alone and in combination, on body weight, food efficiency radio, kidney function and renal histology in experimentally hyperuricemic rats. The experiment was performed using 4 groups of Sprague Dawley rats fed on basal diet supplemented with potassium oxonate [uricase inhibitor] at 2% for 6 weeks to induce experimental hyperuricemia and one group was fed on basal diet only and used as a negative control group. Four experimental diets were prepared by adding the dry powder of celery seeds, chicory leaves or barley grains at 10% or mixture of three plants at 15% [5% from each] to basal diet. The feeding period was 4 weeks. Biochemical analysis of blood urea nitrogen, uric acid and creatinine concentrations in the serum as well as histopathological examination of kidney were performed. Results showed that feeding of celery, chicory and barley mixture at 15% to hyperuricemic rats for 4 weeks increased body weight and improved feed efficiency. It decreased the elevated serum urea nitrogen, uric acid and creatinine concentrations. It also produced an excellent effect on renal histology as it ameliorated the renal damage caused by elevated serum uric acid. The study suggests that dietary intake of plant mixture of celery, chicory and barley at 15% concentration for 4 weeks may be beneficial to patients suffering from hyperuricemia and kidney disease because it improves the function and structure of kidney in hyperuricemic rats

Effect of parsley on both healthy rats and those suffering from acute renal failure

The Present work was conducted to study the effect of parsley on both health rats and those suffering from acute renal failure [ARF] on the nutritional value, the relative ratio of organs to body weight, blood lipid parameters, kidney and liver functions. Thirty male albino rats [Sprague - Dawaley strain] weighting [200 +/- 5 g] divided into three main groups. The first main group [5 rats] fed on basal diet [control negative group]. The second main group [10 rats] divided to two subgroups and fed on basal diets containing 2% and 5% dried parsley. The third main group [15 rats] injected subcutaneous with glycerol [50%, W/v in saline solution] 10 ml/ kg body weight to induce acute renal failure [ARF] and divided into three subgroups, the first fed on basal diet as a [control positive], while second and third subgroups fed on basal diet containing 2% and 5% dried parsley, respectively. The result revealed that, feeding rats, which suffering from ARF on basal diet containing dried parsley [2% and 5%] resulted in improvement on the nutritional value as well as healthy groups, organs weight/body weight relative ratio, serum cholesterol, triglycerides, low density lipoprotein cholesterol [LDL-c], high density lipoprotein cholesterol [HDL-c], very low density lipoprotein cholesterol [VLDL-c], uric acid, urea nitrogen, aspartate amino transferase [AST] and alanine amino transferase [ALT] than the control positive group. It was concluded that parsley at high concentration 5% realized the best effect on lipid profile, kidney and liver functions