ABSTRACT
Objective:To investigate the effect of catgut implantation at acupoint,Compound Erxian Decoction on levels of serum cytokine in ovariectomized rats.Methods:Sixty 3-month-old female Sprague-drawley rats,weighed 230?20g each,were divided into six groups,ten rats in each group.The first group were sham-operated(Sham-G),while the remaining groups,established by excising both sides ovary,were catgut-acupuncture group(CAG),Chinese herb group(CHG),catgut-acupuncture plus Chinese herb group(CCG),estrogen group(EG)and model group(MG).There wasn’t any therapy in sham-operated group and model group.After 12 weeks corresponding therapy,all groups were sacrificed to procure blood serum for testing the contents of E 2 ,GM-CSF,IGF-1,TNF-?by means of radioimmunoassay and both retral thighbone for testing bone mineral density(BMD) and bone mineral content(BMC)in each specimen.Results:The BMD and BMC of thighbone,E 2 and IGF-1 of serum and in CAG,CHG,CCG and EG was compared with Sham-G,there was no significant difference,but which was higher than MG(P
ABSTRACT
Objective:To investigate the effect of the acupoint catgut embedding and the traditional Chinese medicine on leptin and NPY of castrated rats and the regulating action of the both treatments to HPGA.Methods:To copy castration model by cutting double ovaries of female adult rats,then divide them into groups,after treatments,to observe the weights of castration rats,Lee's index,abdominal cavity fat content and wet weight,serum E 2 ,FSH,Leptin,NPY,GnRH,the number of OB-R positive cells and the change of fatty cells'counting.Results:After treatment,obesity indexes of the each group were unevenly decreased. The level of LP,NPY,GnRH,FSH decreased;the level of E 2 and the number of OB-R positive cells increased.Conclusion:The treatment of the acupoint catgut embedding and TCM can improve the imbalance of HPGA,Leptin resistance and have the effect of losing of weight as well.