ABSTRACT
Leprosy is a chronic disease with clinical presentations according to the immunologic spectrum. Lepromatous form is the most advanced, with the highest transmissibility and risk of causing disabilities. Lucio’s phenomenon is a rare manifestation among lepromatous patients with a rapid and severe evolution and high mortality. It is difficult to differentiate from ulcerative/necrotic erythema nodosum leprosum and has no consensus on how it should be treated. This article is a qualitative review of the literature after the introduction of multidrug therapy, aiming to bring consensus related to the clinical, laboratory and histopathological diagnostic criteria of the disease and its management
ABSTRACT
Objetivo: Avaliar o significado da evidência da isquemia miocárdica e a ocorrência de eventos cardiovasculares na Síndrome Cardíca X (SCX), comparando com doença coronária obstrutiva inicial (DAC <- 50 por cento). Métodos: Estudo observacional de coorte, em, amostra de 605 pacientes (população fonte de 5.137 indivíduos), com ecocardiografia sob estresse físico (EEF) positiva para isquemia miocárdica, os quais foram submetidos à cineangiocoronariografia, e divididos, posteriormente, em 2 grupos: G1 (SCX, n=64) e G2 (DAC<- 50 por cento, n=84). Os pacientes foram comparados quanto às características clínicas, parâmetros ergométricos e ecocardiográficos, e seguidos po +- 43,8 meses (mínimo de 12 meses e máximo de 85 meses), quanto ao surgimento de ngina típica, infarto agudo do miocárdico...
Subject(s)
Humans , Male , Female , Middle Aged , Microvascular Angina/complications , Microvascular Angina/diagnosis , Coronary Artery Disease/complications , Coronary Artery Disease/diagnosis , Echocardiography, Stress/methods , Echocardiography, Stress , Myocardial Ischemia/diagnosis , Risk FactorsABSTRACT
A malária, conhecida também como paludismo é uma doenca infecciosa do tipo febril, causada por protozoários do gênero Plasmodium, transmitida pela picada de um mosquito do gênero Anopheles. Ocorre, sobretudo, em áreas tropicais da África, da Ásia, da Amética Latina e do Pacífico sul-ocidental. A doença se apresenta de diversas formas, inclusive quadros graves, podendo se transformar em urgência, com complicações e óbito. Os autores apresentam o caso de um paciente que deu entrada em seu serviço com quadro de febre alta, calafrios e história de viagem recente a área endêmica de malália. Houve dificuldade no diagnóstico, devido à epidemia de outras doenças infecciosas e febris em nosso meio, como o dengue. Foi feito o diagnóstico de malária e, apesar da introdução da mediciação específica, o paciente evoluiu rapidamente para síndrome da resposta inflamatória sistêmica e choque, não sendo possível revertê-la, culminando com óbito
Subject(s)
Humans , Malaria , Plasmodium falciparum , Plasmodium malariae , Plasmodium vivax , Risk FactorsABSTRACT
INTRODUCTION: Unilateral ureteral obstruction breaks out events that cause the transitory increase of glomerular permeability to macromolecules, both in the obstructed kidney and in the contralateral kidney, suggesting the presence of some factor, with a systemic action, liberated as a response to the obstruction. We know that the rennin-angiotensin system is activated by acute ureteral obstruction. We have developed an experiment to assess the role of angiotensin II on the glomerular permeability to IgG due to acute ureteral obstruction, using enalaprilat, an angiotensin enzyme conversion inhibitor, to block the effects of the activation of the rennin-angiotensin system. MATERIALS AND METHODS: We have used 45 adult Wistar female rats, distributed into 3 main groups: a control group with 5 animals and 2 experiment groups each one with 10 animals submitted to unilateral ureteral obstruction and nephrectomy at 60 and 120 minutes. Each experiment group had its simulation correspondent (sham). We have studied both kidneys through the direct immunofluorescence method. RESULTS: We have found positive permeation in animals without enalaprilat in both kidneys and negative permeation in those in which the drug was used. CONCLUSION: We have concluded that enalaprilat interferes in this alteration of permeability, suggesting that angiotensin II is involved in the loss of selectivity of the glomerular membrane.
Subject(s)
Animals , Female , Rats , Angiotensin-Converting Enzyme Inhibitors/pharmacology , Enalaprilat/pharmacology , Glomerular Filtration Rate/drug effects , Immunoglobulin G/metabolism , Macromolecular Substances/metabolism , Ureteral Obstruction/metabolism , Acute Disease , Disease Models, Animal , Fluorescent Antibody Technique, Direct , Permeability/drug effects , Rats, Wistar , Time FactorsABSTRACT
The author report a case of breast sarcoma. The surgical therapy was an Auchincloss - Madden mastectomy associated with chemoterapy and radioterapy. This kind of therapy was due to peculiarities of the patient's neoplasm. Local recurrence was observed twice and pulmonary and liver metastases. Death occurred ten months after diagnosis